{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(1)"],"submitter":["Yao T"],"pubmed_abstract":["<h4>Background</h4>We have previously found there was a small subpopulation of cells with cancer stem cell-like phenotype ALDH-1 in cervical cancer. Radiotherapy has been applied in most of the cervical cancer. However,the mechanisms underlying radioresistance still remained elusive. Our study is to explore whether ALDH+ cell promotes radioresistance by hypoxia.<h4>Methods</h4>Cells were respectively cultured in hypoxia and normoxia environment and analyzed for marker stability, and cell cycle distribution.<h4>Results</h4>Cell growth, apoptosis, cell cycle, sphere formation were affected by hypoxia. ALDH-1 and CHK2 were upregulated after hypoxia.<h4>Conclusions</h4>Here we show that ALDH-1 positive cells contribute to cervical carcinoma radioresistance through preferential activation of th"],"journal":["BMC cancer"],"pagination":["891"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7499852"],"repository":["biostudies-literature"],"pubmed_title":["ALDH-1-positive cells exhibited a radioresistant phenotype that was enhanced with hypoxia in cervical cancer."],"pmcid":["PMC7499852"],"pubmed_authors":["Peng Y","Huang C","Yao Y","Li J","Lin R","Weng X","Yao T","Lin Z"],"additional_accession":[]},"is_claimable":false,"name":"ALDH-1-positive cells exhibited a radioresistant phenotype that was enhanced with hypoxia in cervical cancer.","description":"<h4>Background</h4>We have previously found there was a small subpopulation of cells with cancer stem cell-like phenotype ALDH-1 in cervical cancer. Radiotherapy has been applied in most of the cervical cancer. However,the mechanisms underlying radioresistance still remained elusive. Our study is to explore whether ALDH+ cell promotes radioresistance by hypoxia.<h4>Methods</h4>Cells were respectively cultured in hypoxia and normoxia environment and analyzed for marker stability, and cell cycle distribution.<h4>Results</h4>Cell growth, apoptosis, cell cycle, sphere formation were affected by hypoxia. ALDH-1 and CHK2 were upregulated after hypoxia.<h4>Conclusions</h4>Here we show that ALDH-1 positive cells contribute to cervical carcinoma radioresistance through preferential activation of th","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2025-05-31T23:16:42.254Z","creation":"2020-09-25T07:03:26Z"},"accession":"S-EPMC7499852","cross_references":{"pubmed":["32942996"],"doi":["10.1186/s12885-020-07337-8"]}}