biostudies-literatureImhof TDeutsche ForschungsgemeinschaftProjekt DEAL15320https://www.ebi.ac.uk/biostudies/studies/S-EPMC7501263biostudies-literatureUnknown10(1)Odontoblasts and pulp stroma cells are embedded within supramolecular networks of extracellular matrix (ECM). Fibrillin microfibrils and associated proteins are crucial constituents of these networks, serving as contextual scaffolds to regulate tissue development and homeostasis by providing both structural and mechanical properties and sequestering growth factors of the TGF-β superfamily. EMILIN-1, -2, and -3 are microfibril-associated glycoproteins known to modulate cell behaviour, growth factor activity, and ECM assembly. So far their expression in the various cells of the dentin-pulp complex during development, in the adult stage, and during inflammation has not been investigated. Confocal immunofluorescence microscopy and western blot analysis of developing and adult mouse molars and Scientific reportsEMILIN proteins are novel extracellular constituents of the dentin-pulp complex.PMC7501263FOR2722/ C2FOR2722/ B2SFB829Koch MSengle GImhof TKorkmaz YSchiavinato AfalseEMILIN proteins are novel extracellular constituents of the dentin-pulp complex.Odontoblasts and pulp stroma cells are embedded within supramolecular networks of extracellular matrix (ECM). Fibrillin microfibrils and associated proteins are crucial constituents of these networks, serving as contextual scaffolds to regulate tissue development and homeostasis by providing both structural and mechanical properties and sequestering growth factors of the TGF-β superfamily. EMILIN-1, -2, and -3 are microfibril-associated glycoproteins known to modulate cell behaviour, growth factor activity, and ECM assembly. So far their expression in the various cells of the dentin-pulp complex during development, in the adult stage, and during inflammation has not been investigated. Confocal immunofluorescence microscopy and western blot analysis of developing and adult mouse molars and 2020-01-01T00:00:00Z2020 Sep2025-05-18T11:49:29.212Z2025-05-18T11:49:29.212ZS-EPMC75012633294878510.1038/s41598-020-72123-2