{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang SH"],"funding":["Auckland Medical Research Foundation"],"pagination":["1041-1047"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7513673"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(9)"],"pubmed_abstract":["The synthesis and biological activity of 42 novel <i>S</i>-lipidated analogues of a connexin 43 channel inhibitory Peptide5 is described. Unmodified Peptide5 moderates hemichannels and gap junctions that are both implicated in the progression of neurological disease. Peptide5 was site-specifically modified with a cysteine residue, which then underwent thiol-ene mediated <i>S</i>-lipidation to afford <i>S</i>-lipidated Peptide5 analogues containing straight-chain, branched, or aromatic lipids. The modified peptides were assessed for their effect on hemichannel opening and the most promising candidates were evaluated in serum stability studies."],"journal":["RSC medicinal chemistry"],"pubmed_title":["Synthesis and biological evaluation of <i>S</i>-lipidated lipopeptides of a connexin 43 channel inhibitory peptide."],"pmcid":["PMC7513673"],"funding_grant_id":["1117016"],"pubmed_authors":["O'Carroll SJ","Yang SH","Brimble MA","Clemett CA","Harris PWR"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis and biological evaluation of <i>S</i>-lipidated lipopeptides of a connexin 43 channel inhibitory peptide.","description":"The synthesis and biological activity of 42 novel <i>S</i>-lipidated analogues of a connexin 43 channel inhibitory Peptide5 is described. Unmodified Peptide5 moderates hemichannels and gap junctions that are both implicated in the progression of neurological disease. Peptide5 was site-specifically modified with a cysteine residue, which then underwent thiol-ene mediated <i>S</i>-lipidation to afford <i>S</i>-lipidated Peptide5 analogues containing straight-chain, branched, or aromatic lipids. The modified peptides were assessed for their effect on hemichannel opening and the most promising candidates were evaluated in serum stability studies.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2026-05-07T19:15:43.407Z","creation":"2025-05-18T13:36:13.715Z"},"accession":"S-EPMC7513673","cross_references":{"pubmed":["33479696"],"doi":["10.1039/d0md00172d"]}}