biostudies-literatureHuang KAChang Gung Memorial Hospitale1008857https://www.ebi.ac.uk/biostudies/studies/S-EPMC7521691biostudies-literatureUnknown16(9)An outbreak of the hand-foot-mouth disease with severe neurological cases, mainly caused by the genotype C1 enterovirus A71 (EV-A71), occurred in Taiwan between 2018 and early 2019. In the recent decade, the most dominant EV-A71 genotypes in Taiwan were B5 and C4 but changed to C1 in 2018. Antibody-mediated immunity plays a key role in limiting the EV-A71 illness in humans. However, the level of neutralizing activities against genotype C1 virus by human polyclonal and monoclonal antibodies (MAbs) remains largely unclear. In the study, we demonstrated that that 39% (9 in 23) of post-infection sera from the genotype B5- or C4-infected patients in 2014-2017 exhibit reduced titers with the 2018-2019 genotype C1 viruses than with the earlier B5 and C4 viruses tested. This finding with polyclonaPLoS pathogensEmergence of genotype C1 Enterovirus A71 and its link with antigenic variation of virus in Taiwan.PMC7521691CORPG3J0111Huang PNChiu CHYang SLHuang KATsao KCHuang YCLin TYShih SRfalseEmergence of genotype C1 Enterovirus A71 and its link with antigenic variation of virus in Taiwan.An outbreak of the hand-foot-mouth disease with severe neurological cases, mainly caused by the genotype C1 enterovirus A71 (EV-A71), occurred in Taiwan between 2018 and early 2019. In the recent decade, the most dominant EV-A71 genotypes in Taiwan were B5 and C4 but changed to C1 in 2018. Antibody-mediated immunity plays a key role in limiting the EV-A71 illness in humans. However, the level of neutralizing activities against genotype C1 virus by human polyclonal and monoclonal antibodies (MAbs) remains largely unclear. In the study, we demonstrated that that 39% (9 in 23) of post-infection sera from the genotype B5- or C4-infected patients in 2014-2017 exhibit reduced titers with the 2018-2019 genotype C1 viruses than with the earlier B5 and C4 viruses tested. This finding with polyclona2020-01-01T00:00:00Z2020 Sep2026-05-03T22:47:04.277Z2020-10-29T08:42:19ZS-EPMC75216913293683810.1371/journal.ppat.1008857