{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["135"],"submitter":["COVID-19 RISk and Treatments (CORIST) Collaboration"],"pubmed_abstract":["<h4>Objective</h4>The hypothesis that been set forward that use of Renin Angiotensin Aldosterone System (RAAS) inhibitors is associated with COVID-19 severity. We set-up a multicenter Italian collaboration (CORIST Project, ClinicalTrials.gov ID: NCT04318418) to retrospectively investigate the relationship between RAAS inhibitors and COVID-19 in-hospital mortality. We also carried out an updated meta-analysis on the relevant studies.<h4>Methods</h4>We analyzed 4069 unselected patients with laboratory-confirmed SARS-CoV-2 infection and hospitalized in 34 clinical centers in Italy from February 19, 2020 to May 23, 2020. The primary end-point in a time-to event analysis was in-hospital death, comparing patients who received angiotensin-converting-enzyme inhibitors (ACEI) or angiotensin-recepto"],"journal":["Vascular pharmacology"],"pagination":["106805"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7521934"],"repository":["biostudies-literature"],"pubmed_title":["RAAS inhibitors are not associated with mortality in COVID-19 patients: Findings from an observational multicenter study in Italy and a meta-analysis of 19 studies."],"pmcid":["PMC7521934"],"pubmed_authors":["Aucella F","Marotta C","Cingolani A","Signorelli C","Menicanti L","Cianfrone S","Rossi M","Leone A","Al Moghazi S","Sangiovanni V","Scoppettuolo G","Mennuni M","Pinchera B","Guarnieri G","Cascio A","Di Castelnuovo A","Mancarella S","Poletti V","Caiano L","Graziani E","Scorzolini L","Sgariglia R","Colombo C","Mastroianni F","Gentile I","Costanzo S","Agostoni P","Vianello A","Odone A","Danzi GB","Iacoviello L","Barchitta M","Maresca G","Ravaglia C","Bonaccio M","Minutolo F","Aiello L","Lio V","de Gaetano Donati K","Patti G","Antinori A","Mussinelli R","Marcucci R","Vettor R","Berselli N","D'Ardes D","Perlini S","Mengozzi A","Arboretti R","Marongiu S","Menichetti F","Milic J","Barbieri G","Sanrocco C","Vinceti M","Manuele R","Carrozzi L","Parruti G","COVID-19 RISk and Treatments (CORIST) Collaboration","Gialluisi A","Cozzi O","Marra L","Santilli F","Pasi E","Di Tano G","Colomba C","Rossato M","Vergori A","Cipollone F","Mazzitelli M","Guaraldi G","Castiglione G","Pesavento R","Fusco FM","Larizza G","Cauda R","Simeone PG","Virano A","D'Offizi G","Musso M","Stefanini GG","Meschiari M","Maitan S","Molena B","Abete P","My I","Ciccullo A","Crisetti A","Mapelli M","Bonfanti P","Cacciatore F","Maccagni G","Maragna R","Olivieri M","Di Gennaro F","Pivato CA","De Caterina R","Vocciante L","Ageno W","Salinaro F","Crosta F","Palimodde A","Madaro F","Lucia MB","Trecarichi EM","Bartoloni A","Petri F","Blandi L","Mussini C","Sabena A"],"additional_accession":[]},"is_claimable":false,"name":"RAAS inhibitors are not associated with mortality in COVID-19 patients: Findings from an observational multicenter study in Italy and a meta-analysis of 19 studies.","description":"<h4>Objective</h4>The hypothesis that been set forward that use of Renin Angiotensin Aldosterone System (RAAS) inhibitors is associated with COVID-19 severity. We set-up a multicenter Italian collaboration (CORIST Project, ClinicalTrials.gov ID: NCT04318418) to retrospectively investigate the relationship between RAAS inhibitors and COVID-19 in-hospital mortality. We also carried out an updated meta-analysis on the relevant studies.<h4>Methods</h4>We analyzed 4069 unselected patients with laboratory-confirmed SARS-CoV-2 infection and hospitalized in 34 clinical centers in Italy from February 19, 2020 to May 23, 2020. The primary end-point in a time-to event analysis was in-hospital death, comparing patients who received angiotensin-converting-enzyme inhibitors (ACEI) or angiotensin-recepto","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2026-05-02T17:08:20.441Z","creation":"2020-10-08T07:13:14Z"},"accession":"S-EPMC7521934","cross_references":{"pubmed":["32992048"],"doi":["10.1016/j.vph.2020.106805"]}}