{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Gaglio D"],"funding":["Ministero dell’Istruzione, dell’Università e della Ricerca"],"pubmed_abstract":["<h4>Abstract</h4><h4>Background</h4>Rewiring of metabolism induced by oncogenic <i>K-Ras</i> in cancer cells involves both glucose and glutamine utilization sustaining enhanced, unrestricted growth. The development of effective anti-cancer treatments targeting metabolism may be facilitated by the identification and rational combinatorial targeting of metabolic pathways.<h4>Methods</h4>We performed mass spectrometric metabolomics analysis in vitro and in vivo experiments to evaluate the efficacy of drugs and identify metabolic connectivity.<h4>Results</h4>We show that <i>K-Ras</i>-mutant lung and colon cancer cells exhibit a distinct metabolic rewiring, the latter being more dependent on respiration. Combined treatment with the glutaminase inhibitor CB-839 and the PI3K/aldolase inhibitor NV"],"journal":["Cancer & metabolism"],"pagination":["22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7523077"],"repository":["biostudies-literature"],"pubmed_title":["Disruption of redox homeostasis for combinatorial drug efficacy in <i>K-Ras</i> tumors as revealed by metabolic connectivity profiling."],"pmcid":["PMC7523077"],"pubmed_authors":["Napodano E","Valtorta S","Papa F","Camboni T","Metallo CM","Colangelo AM","Alberghina L","Paci P","Raccagni I","Moresco RM","Vanoni M","Bharat R","Parker SJ","Conte F","Bonanomi M","Righi N","Cifola I","Fiscon G","Ripamonti M","Gaglio D"],"additional_accession":[]},"is_claimable":false,"name":"Disruption of redox homeostasis for combinatorial drug efficacy in <i>K-Ras</i> tumors as revealed by metabolic connectivity profiling.","description":"<h4>Abstract</h4><h4>Background</h4>Rewiring of metabolism induced by oncogenic <i>K-Ras</i> in cancer cells involves both glucose and glutamine utilization sustaining enhanced, unrestricted growth. The development of effective anti-cancer treatments targeting metabolism may be facilitated by the identification and rational combinatorial targeting of metabolic pathways.<h4>Methods</h4>We performed mass spectrometric metabolomics analysis in vitro and in vivo experiments to evaluate the efficacy of drugs and identify metabolic connectivity.<h4>Results</h4>We show that <i>K-Ras</i>-mutant lung and colon cancer cells exhibit a distinct metabolic rewiring, the latter being more dependent on respiration. Combined treatment with the glutaminase inhibitor CB-839 and the PI3K/aldolase inhibitor NV","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-05-29T22:10:12.629Z","creation":"2025-05-29T22:10:12.629Z"},"accession":"S-EPMC7523077","cross_references":{"pubmed":["33005401"],"doi":["10.1186/s40170-020-00227-4"]}}