biostudies-literatureTipton PWResearch FoundationMayo Clinic LBD Functional Genomics ProgramSol Goldman Charitable TrustMayo Clinic Center for Regenerative MedicineNINDS NIH HHSDepartment of DefenseUSFox FoundationLittle Family Foundation16-18https://www.ebi.ac.uk/biostudies/studies/S-EPMC7528207biostudies-literatureUnknown73We aimed to replicate a recent study that found a high frequency of the GBA p.K198E mutant in Colombian patients with PD. We identified the p.K198E substitution at a lower frequency in our cohort of Colombians with PD (2.1%), and this was not significantly different than controls (1.7%, P = 0.86) emphasizing the need for larger genetic studies in Latin America.Parkinsonism & related disordersPrevalence of GBA p.K198E mutation in Colombian and Hispanic populations.PMC7528207R01 NS078086BHV3241-301U54 NS110435U54 NS100693P50 NS072187M15-562M15-563BHV4157-206W81XWH-17-1-0249Moreno-Lopez CLWszolek ZKRomero-Osorio OTipton PWSoto-Beasley AIRoss OACerquera-Cleves CWalton RLDiaz CSoler-Rangel SfalsePrevalence of GBA p.K198E mutation in Colombian and Hispanic populations.We aimed to replicate a recent study that found a high frequency of the GBA p.K198E mutant in Colombian patients with PD. We identified the p.K198E substitution at a lower frequency in our cohort of Colombians with PD (2.1%), and this was not significantly different than controls (1.7%, P = 0.86) emphasizing the need for larger genetic studies in Latin America.2020-01-01T00:00:00Z2020 Apr2026-05-07T16:44:10.918Z2022-02-09T10:13:55.919ZS-EPMC75282073219719710.1016/j.parkreldis.2020.03.008