{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hao W"],"funding":["Tianjin University","Natural Science Foundation of Tianjin City","National Natural Science Foundation of China"],"pagination":["24537-24545"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7528291"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(38)"],"pubmed_abstract":["Atomically precise Au<sub>25</sub>(SG)<sub>18</sub> clusters have shown great promise in near-infrared II cerebrovascular imaging, X-ray imaging, and cancer radiotherapy due to their high atomic number, unique molecular-like electronic structure, and renal clearable properties. Therefore, it is important to study the in vivo toxicity of Au<sub>25</sub> clusters. Unfortunately, previous toxicological investigations focused on low injected doses (<100 mg kg<sup>-1</sup>) and routine research methods, such as blood chemistry and biochemistry, which cannot reflect neurotoxicity or tiny changes in neural activity. In this work, in vivo neuroelectrophysiology of Au<sub>25</sub> clusters at ultrahigh injected doses (200, 300, and 500 mg kg<sup>-1</sup>) was investigated. Local field potential sho"],"journal":["ACS omega"],"pubmed_title":["In Vivo Neuroelectrophysiological Monitoring of Atomically Precise Au<sub>25</sub> Clusters at an Ultrahigh Injected Dose."],"pmcid":["PMC7528291"],"funding_grant_id":["U1932107","19JCZDJC34000","91859101","81971744","81471786"],"pubmed_authors":["Liu H","Mu X","Chen K","Zhang XD","Xin Q","Hao W","Liu S"],"additional_accession":[]},"is_claimable":false,"name":"In Vivo Neuroelectrophysiological Monitoring of Atomically Precise Au<sub>25</sub> Clusters at an Ultrahigh Injected Dose.","description":"Atomically precise Au<sub>25</sub>(SG)<sub>18</sub> clusters have shown great promise in near-infrared II cerebrovascular imaging, X-ray imaging, and cancer radiotherapy due to their high atomic number, unique molecular-like electronic structure, and renal clearable properties. Therefore, it is important to study the in vivo toxicity of Au<sub>25</sub> clusters. Unfortunately, previous toxicological investigations focused on low injected doses (<100 mg kg<sup>-1</sup>) and routine research methods, such as blood chemistry and biochemistry, which cannot reflect neurotoxicity or tiny changes in neural activity. In this work, in vivo neuroelectrophysiology of Au<sub>25</sub> clusters at ultrahigh injected doses (200, 300, and 500 mg kg<sup>-1</sup>) was investigated. Local field potential sho","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2025-04-04T07:40:44.273Z","creation":"2025-04-04T07:40:44.273Z"},"accession":"S-EPMC7528291","cross_references":{"pubmed":["33015471"],"doi":["10.1021/acsomega.0c03005"]}}