{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mao H"],"funding":["Shanghai Municipal Education Commission","National Natural Science Foundation of China","Shanghai Science and Technology Commission","Shanghai Institute of Technology"],"pagination":["24526-24536"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7528326"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(38)"],"pubmed_abstract":["3-methoxy-4-hydroxymandelic acid (VMA) was the critical intermediate for the synthesis of vanillin by the glyoxylic acid method. Meanwhile, a valuable byproduct (2-hydroxy-3-methoxy-mandelic acid, <i>o</i>-VMA) was obtained during the reaction. Al<sup>3+</sup> was found to be a helpful catalyst in increasing the selectivity for VMA and <i>o</i>-VMA. In the presence of Al<sup>3+</sup>, the selectivity for VMA and <i>o</i>-VMA increased from 83 to 88% and from 3 to 8%, respectively, while that of the helpless byproduct 2-hydroxy-3-methoxy-1,5-mandelic acid (di-VMA) decreased from 14% to less than 4%. The kinetics based on the kinetic equation of the condensation reaction was studied by the initial concentration method. The results indicated that the involvement of Al<sup>3+</sup> could reduc"],"journal":["ACS omega"],"pubmed_title":["Effect and Mechanism of Aluminum(III) for Guaiacol-Glyoxylic Acid Condensation Reaction in Vanillin Production."],"pmcid":["PMC7528326"],"funding_grant_id":["39120K186028- YJ2018-7","21906105","15120503700"],"pubmed_authors":["Meng T","Liu J","Xiao Z","Wang C","Hu X","Mao H","Wang H","Zhang C"],"additional_accession":[]},"is_claimable":false,"name":"Effect and Mechanism of Aluminum(III) for Guaiacol-Glyoxylic Acid Condensation Reaction in Vanillin Production.","description":"3-methoxy-4-hydroxymandelic acid (VMA) was the critical intermediate for the synthesis of vanillin by the glyoxylic acid method. Meanwhile, a valuable byproduct (2-hydroxy-3-methoxy-mandelic acid, <i>o</i>-VMA) was obtained during the reaction. Al<sup>3+</sup> was found to be a helpful catalyst in increasing the selectivity for VMA and <i>o</i>-VMA. In the presence of Al<sup>3+</sup>, the selectivity for VMA and <i>o</i>-VMA increased from 83 to 88% and from 3 to 8%, respectively, while that of the helpless byproduct 2-hydroxy-3-methoxy-1,5-mandelic acid (di-VMA) decreased from 14% to less than 4%. The kinetics based on the kinetic equation of the condensation reaction was studied by the initial concentration method. The results indicated that the involvement of Al<sup>3+</sup> could reduc","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2026-07-15T21:44:46.894Z","creation":"2025-04-06T16:46:38.44Z"},"accession":"S-EPMC7528326","cross_references":{"pubmed":["33015470"],"doi":["10.1021/acsomega.0c03003"]}}