{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ozdas MS"],"funding":["European Research Council","NCI NIH HHS"],"pagination":["4929"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7529901"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Non-invasive, molecularly-specific, focal modulation of brain circuits with low off-target effects can lead to breakthroughs in treatments of brain disorders. We systemically inject engineered ultrasound-controllable drug carriers and subsequently apply a novel two-component Aggregation and Uncaging Focused Ultrasound Sequence (AU-FUS) at the desired targets inside the brain. The first sequence aggregates drug carriers with millimeter-precision by orders of magnitude. The second sequence uncages the carrier's cargo locally to achieve high target specificity without compromising the blood-brain barrier (BBB). Upon release from the carriers, drugs locally cross the intact BBB. We show circuit-specific manipulation of sensory signaling in motor cortex in rats by locally concentrating and rele"],"journal":["Nature communications"],"pubmed_title":["Non-invasive molecularly-specific millimeter-resolution manipulation of brain circuits by ultrasound-mediated aggregation and uncaging of drug carriers."],"pmcid":["PMC7529901"],"funding_grant_id":["818179","R01 CA235756"],"pubmed_authors":["Sirsi SR","Patel N","Yanik MF","Shah AS","Bigler L","Stalder U","Johnson PM","Marks M","Ozdas MS","Yasar TB","von der Behrens W"],"additional_accession":[]},"is_claimable":false,"name":"Non-invasive molecularly-specific millimeter-resolution manipulation of brain circuits by ultrasound-mediated aggregation and uncaging of drug carriers.","description":"Non-invasive, molecularly-specific, focal modulation of brain circuits with low off-target effects can lead to breakthroughs in treatments of brain disorders. We systemically inject engineered ultrasound-controllable drug carriers and subsequently apply a novel two-component Aggregation and Uncaging Focused Ultrasound Sequence (AU-FUS) at the desired targets inside the brain. The first sequence aggregates drug carriers with millimeter-precision by orders of magnitude. The second sequence uncages the carrier's cargo locally to achieve high target specificity without compromising the blood-brain barrier (BBB). Upon release from the carriers, drugs locally cross the intact BBB. We show circuit-specific manipulation of sensory signaling in motor cortex in rats by locally concentrating and rele","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-22T20:15:40.294Z","creation":"2020-10-29T10:47:07Z"},"accession":"S-EPMC7529901","cross_references":{"pubmed":["33004789"],"doi":["10.1038/s41467-020-18059-7"]}}