{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Michels KB"],"funding":["World Cancer Research Fund","World Cancer Research Fund UK (WCRF UK)","Foundation for the National Institutes of Health","NCI NIH HHS","Division of Cancer Prevention, National Cancer Institute","PCI Proyecto","NIGMS NIH HHS","FONDECYT"],"pagination":["104"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7531086"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Background
Systemic inflammation may play a role in shaping breast composition, one of the strongest risk factors for breast cancer. Pubertal development presents a critical window of breast tissue susceptibility to exogenous and endogenous factors, including pro-inflammatory markers. However, little is known about the role of systemic inflammation on adolescent breast composition and pubertal development among girls.Methods
We investigated associations between circulating levels of inflammatory markers (e.g., interleukin-6 (IL-6), tumor necrosis factor receptor 2 (TNFR2), and C-reactive protein (CRP)) at Tanner stages 2 and 4 and breast composition at Tanner stage 4 in a cohort of 397 adolescent girls in Santiago, Chile (Growth and Obesity Cohort Study, 2006-2018). Multiva"],"journal":["Breast cancer research : BCR"],"pubmed_title":["Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche."],"pmcid":["PMC7531086"],"funding_grant_id":["K07 CA225856","REDI170060","11170670","R01CA158313","R01 CA158313","P20 GM113134","2010/245","K07CA225856"],"pubmed_authors":["Shepherd J","Corvalan C","Kim CE","Pereira A","Binder AM","Keller K","Santos JL","Michels KB"],"additional_accession":[]},"is_claimable":false,"name":"Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche.","description":"Background
Systemic inflammation may play a role in shaping breast composition, one of the strongest risk factors for breast cancer. Pubertal development presents a critical window of breast tissue susceptibility to exogenous and endogenous factors, including pro-inflammatory markers. However, little is known about the role of systemic inflammation on adolescent breast composition and pubertal development among girls.Methods
We investigated associations between circulating levels of inflammatory markers (e.g., interleukin-6 (IL-6), tumor necrosis factor receptor 2 (TNFR2), and C-reactive protein (CRP)) at Tanner stages 2 and 4 and breast composition at Tanner stage 4 in a cohort of 397 adolescent girls in Santiago, Chile (Growth and Obesity Cohort Study, 2006-2018). Multiva","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-26T13:28:22.066Z","creation":"2020-10-29T08:40:07Z"},"accession":"S-EPMC7531086","cross_references":{"pubmed":["33004039"],"doi":["10.1186/s13058-020-01338-y"]}}