biostudies-literatureMichels KBWorld Cancer Research FundWorld Cancer Research Fund UK (WCRF UK)Foundation for the National Institutes of HealthNCI NIH HHSDivision of Cancer Prevention, National Cancer InstitutePCI ProyectoNIGMS NIH HHSFONDECYT104https://www.ebi.ac.uk/biostudies/studies/S-EPMC7531086biostudies-literatureUnknown22(1)<h4>Background</h4>Systemic inflammation may play a role in shaping breast composition, one of the strongest risk factors for breast cancer. Pubertal development presents a critical window of breast tissue susceptibility to exogenous and endogenous factors, including pro-inflammatory markers. However, little is known about the role of systemic inflammation on adolescent breast composition and pubertal development among girls.<h4>Methods</h4>We investigated associations between circulating levels of inflammatory markers (e.g., interleukin-6 (IL-6), tumor necrosis factor receptor 2 (TNFR2), and C-reactive protein (CRP)) at Tanner stages 2 and 4 and breast composition at Tanner stage 4 in a cohort of 397 adolescent girls in Santiago, Chile (Growth and Obesity Cohort Study, 2006-2018). MultivaBreast cancer research : BCRAssociation between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche.PMC7531086K07 CA225856REDI17006011170670R01CA158313R01 CA158313P20 GM1131342010/245K07CA225856Shepherd JCorvalan CKim CEPereira ABinder AMKeller KSantos JLMichels KBfalseAssociation between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche.<h4>Background</h4>Systemic inflammation may play a role in shaping breast composition, one of the strongest risk factors for breast cancer. Pubertal development presents a critical window of breast tissue susceptibility to exogenous and endogenous factors, including pro-inflammatory markers. However, little is known about the role of systemic inflammation on adolescent breast composition and pubertal development among girls.<h4>Methods</h4>We investigated associations between circulating levels of inflammatory markers (e.g., interleukin-6 (IL-6), tumor necrosis factor receptor 2 (TNFR2), and C-reactive protein (CRP)) at Tanner stages 2 and 4 and breast composition at Tanner stage 4 in a cohort of 397 adolescent girls in Santiago, Chile (Growth and Obesity Cohort Study, 2006-2018). Multiva2020-01-01T00:00:00Z2020 Oct2025-04-26T13:28:22.066Z2020-10-29T08:40:07ZS-EPMC75310863300403910.1186/s13058-020-01338-y