{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang M"],"funding":["International Cooperation and Exchange of the National Natural Science Foundation of China","National Key Research and Development Program of China"],"pagination":["140"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7532624"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["Background
Nanoparticle-based pulmonary drug delivery systems are commonly developed and applied for drug-targeted delivery. They exhibit significant advantages compared to traditional pulmonary drug delivery systems. However, developing the formulation of each drug is a time-consuming and laborious task.Results
In this study, a universal lung-targeting nanoparticle was designed and constructed. The self-assembled micelles were composed of a platycodon secondary saponin, 3-O-β-D-glucopyranosyl platycodigenin 682 (GP-682), based on its specific amphiphilic structure. The GP-682 micelles exhibited a relatively stable zeta potential with a particle size between 60 and 90 nm, and the critical micelle concentration (CMC) value was approximately 42.3 μg/mL. Preincubation of GP-68"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Micelles self-assembled by 3-O-β-D-glucopyranosyl latycodigenin enhance cell membrane permeability, promote antibiotic pulmonary targeting and improve anti-infective efficacy."],"pmcid":["PMC7532624"],"funding_grant_id":["81761168039","Nos. 2018YFC1704800 and 2018YFC1704805"],"pubmed_authors":["Ye L","Cheng D","Jiang Z","Liu K","Huang H","Zhang M","Wu W","Hou Y","Bai G","Shen F"],"additional_accession":[]},"is_claimable":false,"name":"Micelles self-assembled by 3-O-β-D-glucopyranosyl latycodigenin enhance cell membrane permeability, promote antibiotic pulmonary targeting and improve anti-infective efficacy.","description":"Background
Nanoparticle-based pulmonary drug delivery systems are commonly developed and applied for drug-targeted delivery. They exhibit significant advantages compared to traditional pulmonary drug delivery systems. However, developing the formulation of each drug is a time-consuming and laborious task.Results
In this study, a universal lung-targeting nanoparticle was designed and constructed. The self-assembled micelles were composed of a platycodon secondary saponin, 3-O-β-D-glucopyranosyl platycodigenin 682 (GP-682), based on its specific amphiphilic structure. The GP-682 micelles exhibited a relatively stable zeta potential with a particle size between 60 and 90 nm, and the critical micelle concentration (CMC) value was approximately 42.3 μg/mL. Preincubation of GP-68","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-18T17:43:26.061Z","creation":"2024-11-14T01:30:20.148Z"},"accession":"S-EPMC7532624","cross_references":{"pubmed":["33008413"],"doi":["10.1186/s12951-020-00699-y"]}}