biostudies-literatureZhang MInternational Cooperation and Exchange of the National Natural Science Foundation of ChinaNational Key Research and Development Program of China140https://www.ebi.ac.uk/biostudies/studies/S-EPMC7532624biostudies-literatureUnknown18(1)<h4>Background</h4>Nanoparticle-based pulmonary drug delivery systems are commonly developed and applied for drug-targeted delivery. They exhibit significant advantages compared to traditional pulmonary drug delivery systems. However, developing the formulation of each drug is a time-consuming and laborious task.<h4>Results</h4>In this study, a universal lung-targeting nanoparticle was designed and constructed. The self-assembled micelles were composed of a platycodon secondary saponin, 3-O-β-D-glucopyranosyl platycodigenin 682 (GP-682), based on its specific amphiphilic structure. The GP-682 micelles exhibited a relatively stable zeta potential with a particle size between 60 and 90 nm, and the critical micelle concentration (CMC) value was approximately 42.3 μg/mL. Preincubation of GP-68Journal of nanobiotechnologyMicelles self-assembled by 3-O-β-D-glucopyranosyl latycodigenin enhance cell membrane permeability, promote antibiotic pulmonary targeting and improve anti-infective efficacy.PMC753262481761168039Nos. 2018YFC1704800 and 2018YFC1704805Ye LCheng DJiang ZLiu KHuang HZhang MWu WHou YBai GShen FfalseMicelles self-assembled by 3-O-β-D-glucopyranosyl latycodigenin enhance cell membrane permeability, promote antibiotic pulmonary targeting and improve anti-infective efficacy.<h4>Background</h4>Nanoparticle-based pulmonary drug delivery systems are commonly developed and applied for drug-targeted delivery. They exhibit significant advantages compared to traditional pulmonary drug delivery systems. However, developing the formulation of each drug is a time-consuming and laborious task.<h4>Results</h4>In this study, a universal lung-targeting nanoparticle was designed and constructed. The self-assembled micelles were composed of a platycodon secondary saponin, 3-O-β-D-glucopyranosyl platycodigenin 682 (GP-682), based on its specific amphiphilic structure. The GP-682 micelles exhibited a relatively stable zeta potential with a particle size between 60 and 90 nm, and the critical micelle concentration (CMC) value was approximately 42.3 μg/mL. Preincubation of GP-682020-01-01T00:00:00Z2020 Oct2025-04-18T17:43:26.061Z2024-11-14T01:30:20.148ZS-EPMC75326243300841310.1186/s12951-020-00699-y