biostudies-literatureUnknown14Ito S<h4>Aim</h4>To evaluate inter-core laboratory variability of quantitative coronary angiography (QCA) parameters in comparison with intra-core laboratory variability in a randomized controlled trial evaluating drug-eluting stents.<h4>Methods</h4>A total of 50 patients with 62 coronary lesions were analyzed by four analysis experts belonging to an Angiographic Core Laboratory (ACL: 1 expert) and a Cardiovascular Imaging Core Laboratory (CICL: 3 experts). QCA was based on the same standard operating procedure, but selections of projection and cine frames were at the discretion of each analyst. Inter- and intra-core laboratory variabilities were evaluated by accuracy, precision, Bland Altman analysis, and coefficient of variation.<h4>Results</h4>Pre-MLD (minimal lumen diameter) was significantTherapeutic advances in cardiovascular disease1753944720958982https://www.ebi.ac.uk/biostudies/studies/S-EPMC7534069biostudies-literatureInter- and intra-core laboratory variability in the quantitative coronary angiography analysis for drug-eluting stent treatment and follow up.PMC7534069Kinoshita KKami RKotake YNakamura MIto SEndo AfalseInter- and intra-core laboratory variability in the quantitative coronary angiography analysis for drug-eluting stent treatment and follow up.<h4>Aim</h4>To evaluate inter-core laboratory variability of quantitative coronary angiography (QCA) parameters in comparison with intra-core laboratory variability in a randomized controlled trial evaluating drug-eluting stents.<h4>Methods</h4>A total of 50 patients with 62 coronary lesions were analyzed by four analysis experts belonging to an Angiographic Core Laboratory (ACL: 1 expert) and a Cardiovascular Imaging Core Laboratory (CICL: 3 experts). QCA was based on the same standard operating procedure, but selections of projection and cine frames were at the discretion of each analyst. Inter- and intra-core laboratory variabilities were evaluated by accuracy, precision, Bland Altman analysis, and coefficient of variation.<h4>Results</h4>Pre-MLD (minimal lumen diameter) was significant2020-01-01T00:00:00Z2020 Jan-Dec2026-04-30T05:18:25.177Z2020-10-29T09:32:33ZS-EPMC75340693299346410.1177/1753944720958982