{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Uebel CJ"],"funding":["NIGMS NIH HHS"],"pagination":["3719-3728"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7534428"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(10)"],"pubmed_abstract":["RNA interference is a crucial gene regulatory mechanism in <i>Caenorhabditis elegans</i> Phase-separated perinuclear germline compartments called <i>Mutator</i> foci are a key element of RNAi, ensuring robust gene silencing and transgenerational epigenetic inheritance. Despite their importance, <i>Mutator</i> foci regulation is not well understood, and observations of <i>Mutator</i> foci have been largely limited to adult hermaphrodite germlines. Here we reveal that punctate <i>Mutator</i> foci arise in the progenitor germ cells of early embryos and persist throughout all larval stages. They are additionally present throughout the male germline and in the cytoplasm of post-meiotic spermatids, suggestive of a role in paternal epigenetic inheritance. In the adult germline, transcriptional in"],"journal":["G3 (Bethesda, Md.)"],"pubmed_title":["<i>Mutator</i> Foci Are Regulated by Developmental Stage, RNA, and the Germline Cell Cycle in <i>Caenorhabditis elegans</i>."],"pmcid":["PMC7534428"],"funding_grant_id":["T32 GM118289","R35 GM119656"],"pubmed_authors":["Phillips CM","Wallis DC","Agbede D","Uebel CJ"],"additional_accession":[]},"is_claimable":false,"name":"<i>Mutator</i> Foci Are Regulated by Developmental Stage, RNA, and the Germline Cell Cycle in <i>Caenorhabditis elegans</i>.","description":"RNA interference is a crucial gene regulatory mechanism in <i>Caenorhabditis elegans</i> Phase-separated perinuclear germline compartments called <i>Mutator</i> foci are a key element of RNAi, ensuring robust gene silencing and transgenerational epigenetic inheritance. Despite their importance, <i>Mutator</i> foci regulation is not well understood, and observations of <i>Mutator</i> foci have been largely limited to adult hermaphrodite germlines. Here we reveal that punctate <i>Mutator</i> foci arise in the progenitor germ cells of early embryos and persist throughout all larval stages. They are additionally present throughout the male germline and in the cytoplasm of post-meiotic spermatids, suggestive of a role in paternal epigenetic inheritance. In the adult germline, transcriptional in","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-05-29T20:51:37.259Z","creation":"2020-10-29T09:32:12Z"},"accession":"S-EPMC7534428","cross_references":{"pubmed":["32763952"],"doi":["10.1534/g3.120.401514"]}}