biostudies-literatureBendok BRNCATS NIH HHSNorthwestern UniversityMayo Clinic615-624https://www.ebi.ac.uk/biostudies/studies/S-EPMC7534546biostudies-literatureUnknown86(5)<h4>Background</h4>Aneurysm recurrence after coiling has been associated with aneurysm growth, (re)hemorrhage, and a greater need for follow-up. The second-generation HydroCoil Embolic System (HES; MicroVention, Inc) consists of a platinum core with integrated hydrogel and was developed to reduce recurrence through enhancing packing density and healing within the aneurysm.<h4>Objective</h4>To compare recurrence between the second-generation HES and bare platinum coil (BPC) in the new-generation Hydrogel Endovascular Aneurysm Treatment Trial (HEAT).<h4>Methods</h4>HEAT is a randomized, controlled trial that enrolled subjects with ruptured or unruptured 3- to 14-mm intracranial aneurysms amenable to coiling. The primary endpoint was aneurysm recurrence using the Raymond-Roy scale. Secondary NeurosurgeryThe Hydrogel Endovascular Aneurysm Treatment Trial (HEAT): A Randomized Controlled Trial of the Second-Generation Hydrogel Coil.PMC7534546UL1 TR001422Bendok BRPatra DPvan Adel BWard JDWang DTummala RWoo HHDashti SRJindal GCarpenter JAbi-Aad KREl Ahmadieh TYDelgado JJames RDelgado Almandoz JEGrobelny TAoun RJNHussain MMoran CDeshaies EEvans ALuh GDashti SPatsalides AGarg ABozorgchami HSauvageau EAoun SGZammar SGVeznedaroglu EEl Tecle NEScott JAFields JHirsch JLee SChaudry IShankar JFiorella DHEAT Study InvestigatorsJabbour PKanaan HRaymond JKlucznik RAnsari SAPowers CPandey AKelly MLavine SKwasny MJDabus GRahme RJAnsari SAlbuquerque FKalmes DBoulos ASatti SRomero CKniss JFJayaraman MMilot GCortes MDeNardo AJTawk RXavier AHartman JfalseThe Hydrogel Endovascular Aneurysm Treatment Trial (HEAT): A Randomized Controlled Trial of the Second-Generation Hydrogel Coil.<h4>Background</h4>Aneurysm recurrence after coiling has been associated with aneurysm growth, (re)hemorrhage, and a greater need for follow-up. The second-generation HydroCoil Embolic System (HES; MicroVention, Inc) consists of a platinum core with integrated hydrogel and was developed to reduce recurrence through enhancing packing density and healing within the aneurysm.<h4>Objective</h4>To compare recurrence between the second-generation HES and bare platinum coil (BPC) in the new-generation Hydrogel Endovascular Aneurysm Treatment Trial (HEAT).<h4>Methods</h4>HEAT is a randomized, controlled trial that enrolled subjects with ruptured or unruptured 3- to 14-mm intracranial aneurysms amenable to coiling. The primary endpoint was aneurysm recurrence using the Raymond-Roy scale. Secondary 2020-01-01T00:00:00Z2020 May2026-04-08T02:27:39.137Z2020-10-29T09:07:40ZS-EPMC75345463207869210.1093/neuros/nyaa006