biostudies-literatureSingha AAmerican Heart AssociationNIA NIH HHSNational Institutes of HealthUniversity of Texas System588447https://www.ebi.ac.uk/biostudies/studies/S-EPMC7538546biostudies-literatureUnknown11Leptin is a potent endocrine hormone produced by adipose tissue and regulates a broad range of whole-body metabolism such as glucose and lipid metabolism, even without insulin. Central leptin signaling can lower hyperglycemia in insulin-deficient rodents via multiple mechanisms, including improvements of dyslipidemia. However, the specific neurons that regulate anti-dyslipidemia effects of leptin remain unidentified. Here we report that leptin receptors (LEPRs) in neurons expressing Cre recombinase driven by a short fragment of a promoter region of <i>Ins2</i> gene (RIP-Cre^25Mgn neurons) are required for central leptin signaling to reverse dyslipidemia, thereby hyperglycemia in insulin-deficient mice. Ablation of LEPRs in RIP-Cre^25Mgn neurons completely blocks glucoseFrontiers in endocrinologyLeptin Receptors in RIP-Cre^25Mgn Neurons Mediate Anti-dyslipidemia Effects of Leptin in Insulin-Deficient Mice.PMC7538546RF1 AG061872Farmer SPalavicini JPSingha AHan XFujikawa TSandoval DPan MfalseLeptin Receptors in RIP-Cre^25Mgn Neurons Mediate Anti-dyslipidemia Effects of Leptin in Insulin-Deficient Mice.Leptin is a potent endocrine hormone produced by adipose tissue and regulates a broad range of whole-body metabolism such as glucose and lipid metabolism, even without insulin. Central leptin signaling can lower hyperglycemia in insulin-deficient rodents via multiple mechanisms, including improvements of dyslipidemia. However, the specific neurons that regulate anti-dyslipidemia effects of leptin remain unidentified. Here we report that leptin receptors (LEPRs) in neurons expressing Cre recombinase driven by a short fragment of a promoter region of <i>Ins2</i> gene (RIP-Cre^25Mgn neurons) are required for central leptin signaling to reverse dyslipidemia, thereby hyperglycemia in insulin-deficient mice. Ablation of LEPRs in RIP-Cre^25Mgn neurons completely blocks glucose2020-01-01T00:00:00Z20202025-04-19T23:38:26.819Z2025-04-19T23:38:26.819ZS-EPMC75385463307198810.3389/fendo.2020.588447