{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guan X"],"funding":["Hearing Health Foundation","NIDCD NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["16564"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7538896"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Our ability to hear through bone conduction (BC) has long been recognized, but the underlying mechanism is poorly understood. Why certain perturbations affect BC hearing is also unclear. An example is BC hyperacusis (hypersensitive BC hearing)-an unnerving symptom experienced by patients with superior canal dehiscence (SCD). We measured BC-evoked sound pressures in scala vestibuli (P<sub>SV</sub>) and scala tympani (P<sub>ST</sub>) at the basal cochlea in cadaveric human ears, and estimated hearing by the cochlear input drive (P<sub>DIFF</sub> = P<sub>SV</sub> - P<sub>ST</sub>) before and after creating an SCD. Consistent with clinical audiograms, SCD increased BC-driven P<sub>DIFF</sub> below 1 kHz. However, SCD affected the individual scalae pressures in unexpected ways: SCD increased P<"],"journal":["Scientific reports"],"pubmed_title":["Bone-conduction hyperacusis induced by superior canal dehiscence in human: the underlying mechanism."],"pmcid":["PMC7538896"],"funding_grant_id":["R21DC017251","R01DC013303","R21 DC017251","R01 DC013303","Emerging Research Grant 2016"],"pubmed_authors":["Guan X","Lee DJ","Nakajima HH","Cheng YS","Rosowski JJ","Galaiya DJ"],"additional_accession":[]},"is_claimable":false,"name":"Bone-conduction hyperacusis induced by superior canal dehiscence in human: the underlying mechanism.","description":"Our ability to hear through bone conduction (BC) has long been recognized, but the underlying mechanism is poorly understood. Why certain perturbations affect BC hearing is also unclear. An example is BC hyperacusis (hypersensitive BC hearing)-an unnerving symptom experienced by patients with superior canal dehiscence (SCD). We measured BC-evoked sound pressures in scala vestibuli (P<sub>SV</sub>) and scala tympani (P<sub>ST</sub>) at the basal cochlea in cadaveric human ears, and estimated hearing by the cochlear input drive (P<sub>DIFF</sub> = P<sub>SV</sub> - P<sub>ST</sub>) before and after creating an SCD. Consistent with clinical audiograms, SCD increased BC-driven P<sub>DIFF</sub> below 1 kHz. However, SCD affected the individual scalae pressures in unexpected ways: SCD increased P<","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-04T22:09:42.917Z","creation":"2020-10-29T09:06:43Z"},"accession":"S-EPMC7538896","cross_references":{"pubmed":["33024221"],"doi":["10.1038/s41598-020-73565-4"]}}