{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Osinubi A"],"funding":["University of Lagos Central Research Committee"],"pagination":["200906"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7540745"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(9)"],"pubmed_abstract":["Prolinamides are present in secondary metabolites and have wide-ranging biological properties as well as antimicrobial and cytotoxic activities. N-(4'-substituted phenyl)-l-prolinamides 4a-4w were synthesized in two steps, starting from the condensation of p-fluoronitrobenzene 1a-1b with l-proline 2a-2b, under aqueous-alcoholic basic conditions to afford N-aryl-l-prolines 3a-3c, which underwent amidation via a two-stage, one-pot reaction involving SOCl2 and amines, to furnish l-prolinamides in 20-80% yield. The cytotoxicities of 4a-4w against four human carcinoma cell lines (SGC7901, HCT-116, HepG2 and A549) were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-dip"],"journal":["Royal Society open science"],"pubmed_title":["Synthesis and in vitro anticancer activities of substituted N-(4'-nitrophenyl)-l-prolinamides."],"pmcid":["PMC7540745"],"funding_grant_id":["CRC No. 2015/25"],"pubmed_authors":["Gui C","Osinubi A","Bao X","Familoni O","Kong J","Izunobi J","Asekun O"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis and in vitro anticancer activities of substituted N-(4'-nitrophenyl)-l-prolinamides.","description":"Prolinamides are present in secondary metabolites and have wide-ranging biological properties as well as antimicrobial and cytotoxic activities. N-(4'-substituted phenyl)-l-prolinamides 4a-4w were synthesized in two steps, starting from the condensation of p-fluoronitrobenzene 1a-1b with l-proline 2a-2b, under aqueous-alcoholic basic conditions to afford N-aryl-l-prolines 3a-3c, which underwent amidation via a two-stage, one-pot reaction involving SOCl2 and amines, to furnish l-prolinamides in 20-80% yield. The cytotoxicities of 4a-4w against four human carcinoma cell lines (SGC7901, HCT-116, HepG2 and A549) were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-dip","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2026-05-09T03:30:24.25Z","creation":"2020-10-29T09:31:19Z"},"accession":"S-EPMC7540745","cross_references":{"pubmed":["33047051"],"doi":["10.1098/rsos.200906"]}}