biostudies-literatureHolbrook BCNIAID NIH HHSNational Cancer InstituteNCI NIH HHSNIHNIH HHSNational Institute of Allergy and Infectious Diseases, National Institutes of Health2128-2136https://www.ebi.ac.uk/biostudies/studies/S-EPMC7541766biostudies-literatureUnknown205(8)T regulatory cells (Tregs) play a critical role in controlling the immune response, often limiting pathogen-specific cells to curb immune-mediated damage. Studies in human infants have reported an increased representation of Tregs in these individuals. However, how these cells differ from those in adults at various sites and how they respond to activation signals is relatively unknown. In this study, we used a newborn nonhuman primate model to assess Treg populations present at multiple sites with regard to frequency and phenotype in comparison with those present in adult animals. We found that Foxp3⁺ cells were more highly represented in the T cell compartment of newborn nonhuman primates for all sites examined (i.e., the spleen, lung, and circulation). In the spleen and circulJournal of immunology (Baltimore, Md. : 1950)Higher Frequency and Increased Expression of Molecules Associated with Suppression on T Regulatory Cells from Newborn Compared with Adult Nonhuman Primates.PMC7541766R01 AI098339P40 OD010965P30 CA012197P30 CA121291R01 CA121291R01AI098339Holbrook BCAlexander-Miller MAfalseHigher Frequency and Increased Expression of Molecules Associated with Suppression on T Regulatory Cells from Newborn Compared with Adult Nonhuman Primates.T regulatory cells (Tregs) play a critical role in controlling the immune response, often limiting pathogen-specific cells to curb immune-mediated damage. Studies in human infants have reported an increased representation of Tregs in these individuals. However, how these cells differ from those in adults at various sites and how they respond to activation signals is relatively unknown. In this study, we used a newborn nonhuman primate model to assess Treg populations present at multiple sites with regard to frequency and phenotype in comparison with those present in adult animals. We found that Foxp3⁺ cells were more highly represented in the T cell compartment of newborn nonhuman primates for all sites examined (i.e., the spleen, lung, and circulation). In the spleen and circul2020-01-01T00:00:00Z2020 Oct2025-04-21T21:27:30.766Z2022-02-11T12:06:27.663ZS-EPMC75417663287891110.4049/jimmunol.2000461