{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Manrique-Saide P"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS","Innovative Vector Control Consortium","National Institutes of Health","NIH HHS"],"pagination":["839"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7542575"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["<h4>Background</h4>Current urban vector control strategies have failed to contain dengue epidemics and to prevent the global expansion of Aedes-borne viruses (ABVs: dengue, chikungunya, Zika). Part of the challenge in sustaining effective ABV control emerges from the paucity of evidence regarding the epidemiological impact of any Aedes control method. A strategy for which there is limited epidemiological evidence is targeted indoor residual spraying (TIRS). TIRS is a modification of classic malaria indoor residual spraying that accounts for Aedes aegypti resting behavior by applying residual insecticides on exposed lower sections of walls (< 1.5 m), under furniture, and on dark surfaces.<h4>Methods/design</h4>We are pursuing a two-arm, parallel, unblinded, cluster randomized controlled tri"],"journal":["Trials"],"pubmed_title":["The TIRS trial: protocol for a cluster randomized controlled trial assessing the efficacy of preventive targeted indoor residual spraying to reduce Aedes-borne viral illnesses in Merida, Mexico."],"pmcid":["PMC7542575"],"funding_grant_id":["U01 AI148069","R37 AI0032042","U54 GM111274","U01AI148069","R37 AI032042","DFID:30041-105","R01 AI139761"],"pubmed_authors":["Dean NE","Halloran ME","Kirstein OD","Perez PG","Pavia-Ruz N","Gomez-Dantes H","Hladish TJ","Lenhart A","Ayora-Talavera G","Mendez-Vales R","Collins MH","Romer Y","Manrique-Saide P","Che-Mendoza A","Correa-Morales F","Longini IM","Palacio-Vargas J","Vazquez-Prokopec GM","Waller LA"],"additional_accession":[]},"is_claimable":false,"name":"The TIRS trial: protocol for a cluster randomized controlled trial assessing the efficacy of preventive targeted indoor residual spraying to reduce Aedes-borne viral illnesses in Merida, Mexico.","description":"<h4>Background</h4>Current urban vector control strategies have failed to contain dengue epidemics and to prevent the global expansion of Aedes-borne viruses (ABVs: dengue, chikungunya, Zika). Part of the challenge in sustaining effective ABV control emerges from the paucity of evidence regarding the epidemiological impact of any Aedes control method. A strategy for which there is limited epidemiological evidence is targeted indoor residual spraying (TIRS). TIRS is a modification of classic malaria indoor residual spraying that accounts for Aedes aegypti resting behavior by applying residual insecticides on exposed lower sections of walls (< 1.5 m), under furniture, and on dark surfaces.<h4>Methods/design</h4>We are pursuing a two-arm, parallel, unblinded, cluster randomized controlled tri","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2026-05-01T00:31:02.825Z","creation":"2020-10-29T09:31:59Z"},"accession":"S-EPMC7542575","cross_references":{"pubmed":["33032661"],"doi":["10.1186/s13063-020-04780-7"]}}