biostudies-literatureManrique-Saide PNational Institute of Allergy and Infectious DiseasesNIAID NIH HHSInnovative Vector Control ConsortiumNational Institutes of HealthNIH HHS839https://www.ebi.ac.uk/biostudies/studies/S-EPMC7542575biostudies-literatureUnknown21(1)<h4>Background</h4>Current urban vector control strategies have failed to contain dengue epidemics and to prevent the global expansion of Aedes-borne viruses (ABVs: dengue, chikungunya, Zika). Part of the challenge in sustaining effective ABV control emerges from the paucity of evidence regarding the epidemiological impact of any Aedes control method. A strategy for which there is limited epidemiological evidence is targeted indoor residual spraying (TIRS). TIRS is a modification of classic malaria indoor residual spraying that accounts for Aedes aegypti resting behavior by applying residual insecticides on exposed lower sections of walls (< 1.5 m), under furniture, and on dark surfaces.<h4>Methods/design</h4>We are pursuing a two-arm, parallel, unblinded, cluster randomized controlled triTrialsThe TIRS trial: protocol for a cluster randomized controlled trial assessing the efficacy of preventive targeted indoor residual spraying to reduce Aedes-borne viral illnesses in Merida, Mexico.PMC7542575U01 AI148069R37 AI0032042U54 GM111274U01AI148069R37 AI032042DFID:30041-105R01 AI139761Dean NEHalloran MEKirstein ODPerez PGPavia-Ruz NGomez-Dantes HHladish TJLenhart AAyora-Talavera GMendez-Vales RCollins MHRomer YManrique-Saide PChe-Mendoza ACorrea-Morales FLongini IMPalacio-Vargas JVazquez-Prokopec GMWaller LAfalseThe TIRS trial: protocol for a cluster randomized controlled trial assessing the efficacy of preventive targeted indoor residual spraying to reduce Aedes-borne viral illnesses in Merida, Mexico.<h4>Background</h4>Current urban vector control strategies have failed to contain dengue epidemics and to prevent the global expansion of Aedes-borne viruses (ABVs: dengue, chikungunya, Zika). Part of the challenge in sustaining effective ABV control emerges from the paucity of evidence regarding the epidemiological impact of any Aedes control method. A strategy for which there is limited epidemiological evidence is targeted indoor residual spraying (TIRS). TIRS is a modification of classic malaria indoor residual spraying that accounts for Aedes aegypti resting behavior by applying residual insecticides on exposed lower sections of walls (< 1.5 m), under furniture, and on dark surfaces.<h4>Methods/design</h4>We are pursuing a two-arm, parallel, unblinded, cluster randomized controlled tri2020-01-01T00:00:00Z2020 Oct2026-05-01T00:31:02.825Z2020-10-29T09:31:59ZS-EPMC75425753303266110.1186/s13063-020-04780-7