{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(41)"],"submitter":["Liu D"],"pubmed_abstract":["The development of drugs with rapid distribution in the kidney and long-term retention in the renal tubule is a breakthrough for enhanced treatment of acute kidney injury (AKI). Here, l-serine-modified chitosan (SC) was synthesized as a potential AKI kidney-targeting agent due to the native cationic property of chitosan and specific interaction between kidney injury molecule-1 (Kim-1) and serine. Results indicated that SC was rapidly accumulated and long-term retained in ischemia-reperfusion-induced AKI kidneys, especially in renal tubules, which was possibly due to the specific interactions between SC and Kim-1. SC-TK-SS31 was then prepared by conjugating SS31, a mitochondria-targeted antioxidant, to SC via reactive oxygen species (ROS)-sensitive thioketal linker. Because of the effective"],"journal":["Science advances"],"pagination":["eabb7422"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7546709"],"repository":["biostudies-literature"],"pubmed_title":["ROS-responsive chitosan-SS31 prodrug for AKI therapy via rapid distribution in the kidney and long-term retention in the renal tubule."],"pmcid":["PMC7546709"],"pubmed_authors":["You Y","Qi J","Shen Q","Shu G","Chen M","Lou X","Du Y","Jiang S","Wang J","Yu H","Jin F","Sun M","Zhu M","Zhu L","Ying X","Liu D","Xu X"],"additional_accession":[]},"is_claimable":false,"name":"ROS-responsive chitosan-SS31 prodrug for AKI therapy via rapid distribution in the kidney and long-term retention in the renal tubule.","description":"The development of drugs with rapid distribution in the kidney and long-term retention in the renal tubule is a breakthrough for enhanced treatment of acute kidney injury (AKI). Here, l-serine-modified chitosan (SC) was synthesized as a potential AKI kidney-targeting agent due to the native cationic property of chitosan and specific interaction between kidney injury molecule-1 (Kim-1) and serine. Results indicated that SC was rapidly accumulated and long-term retained in ischemia-reperfusion-induced AKI kidneys, especially in renal tubules, which was possibly due to the specific interactions between SC and Kim-1. SC-TK-SS31 was then prepared by conjugating SS31, a mitochondria-targeted antioxidant, to SC via reactive oxygen species (ROS)-sensitive thioketal linker. Because of the effective","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-04T09:15:03.444Z","creation":"2020-10-29T10:54:16Z"},"accession":"S-EPMC7546709","cross_references":{"pubmed":["33036968"],"doi":["10.1126/sciadv.abb7422"]}}