{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":67,"searchCount":0},"additional":{"submitter":["Wang C"],"funding":["Zhejiang Provincial Natural Science Foundation of China","National Natural Science Foundation of China","Zhejiang Medicine Health Science and Technology Program"],"pagination":["102451"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7548987"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28"],"pubmed_abstract":["The thalamus, with the highest density of nicotinic acetylcholine receptor (nAChR) in the brain, plays a central role in thalamo-cortical circuits that are implicated in nicotine addiction. However, little is known about whether the thalamo-cortical circuits are potentially predictive of smoking relapse. In the current study, a total of 125 participants (84 treatment-seeking male smokers and 41 age-matched male nonsmokers) were recruited. Structural and functional magnetic resonance images (MRI) were acquired from all participants. After a 12-week smoking cessation treatment with varenicline, the smokers were then divided into relapsers (n = 54) and nonrelapsers (n = 30). Then, we compared thalamic volume and seed-based thalamo-cortical resting state functional connectivity (rsFC) prior to the cessation treatment among relapsers, nonrelapsers and nonsmokers to investigate the associations between thalamic structure/function and smoking relapse. Increased thalamic volume was detected in smokers relative to nonsmokers, and in relapsers relative to nonrelapsers, especially on the left side. Moreover, decreased left thalamo-precuneus rsFC was detected in relapsers relative to nonrelapsers. Additionally, a logistic regression analysis showed that the thalamic volume and thalamo-precuneus rsFC predicted smoking relapse with an accuracy of 75.7%. These novel findings indicate that increased thalamic volume and decreased thalamo-precuneus rsFC are associated with smoking relapse, and these thalamic measures may be used to predict treatment efficacy of nicotine addiction and serve as a potential biomarker for personalized medicine."],"journal":["NeuroImage. Clinical"],"pubmed_title":["Increased thalamic volume and decreased thalamo-precuneus functional connectivity are associated with smoking relapse."],"pmcid":["PMC7548987"],"funding_grant_id":["LQ18H180001","81701647","81901721","LY21H180017","2018KY418","2017KY080","81171310"],"pubmed_authors":["Qian W","Jiaerken Y","Shen Z","Zeng Q","Yang Y","Wang C","Wang S","Zhang M","Luo X","Li K","Gu Q","Huang P"],"view_count":["67"],"additional_accession":[]},"is_claimable":false,"name":"Increased thalamic volume and decreased thalamo-precuneus functional connectivity are associated with smoking relapse.","description":"The thalamus, with the highest density of nicotinic acetylcholine receptor (nAChR) in the brain, plays a central role in thalamo-cortical circuits that are implicated in nicotine addiction. However, little is known about whether the thalamo-cortical circuits are potentially predictive of smoking relapse. In the current study, a total of 125 participants (84 treatment-seeking male smokers and 41 age-matched male nonsmokers) were recruited. Structural and functional magnetic resonance images (MRI) were acquired from all participants. After a 12-week smoking cessation treatment with varenicline, the smokers were then divided into relapsers (n = 54) and nonrelapsers (n = 30). Then, we compared thalamic volume and seed-based thalamo-cortical resting state functional connectivity (rsFC) prior to the cessation treatment among relapsers, nonrelapsers and nonsmokers to investigate the associations between thalamic structure/function and smoking relapse. Increased thalamic volume was detected in smokers relative to nonsmokers, and in relapsers relative to nonrelapsers, especially on the left side. Moreover, decreased left thalamo-precuneus rsFC was detected in relapsers relative to nonrelapsers. Additionally, a logistic regression analysis showed that the thalamic volume and thalamo-precuneus rsFC predicted smoking relapse with an accuracy of 75.7%. These novel findings indicate that increased thalamic volume and decreased thalamo-precuneus rsFC are associated with smoking relapse, and these thalamic measures may be used to predict treatment efficacy of nicotine addiction and serve as a potential biomarker for personalized medicine.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2024-10-18T15:08:57.71Z","creation":"2020-10-29T09:29:55Z"},"accession":"S-EPMC7548987","cross_references":{"pubmed":["33022581"],"doi":["10.1016/j.nicl.2020.102451"]}}