{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gong Y"],"funding":["STU Scientific Research Foundation for Talents","Guangdong Provincial Special Fund for Modern Agriculture Industry Technology Innovation Teams","Department of Education of Guangdong Province","National Natural Science Foundation of China","Natural Science Foundation of Guangdong Province","Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory"],"pagination":["849-862"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7549984"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Programmed cell death 6 (PDCD6) is a well-known apoptosis regulator that is involved in the immunity of mammals. However, the effects of miRNA-mediated regulation of PDCD6 expression on apoptosis and virus infection in organisms, especially in marine invertebrates, have not been extensively explored. In this study, PDCD6 of mud crab (<i>Scylla paramamosain</i>) (<i>Sp</i>-PDCD6) was characterized. The results showed that <i>Sp</i>-PDCD6 contains five EF-hands domains and could suppress virus infection <i>via</i> apoptosis promotion. It also presented that <i>Sp</i>-PDCD6 was directly targeted by miR-9875 <i>in vitro</i> and <i>in vivo</i>, miR-9875 served as a positive regulator during the virus invasion. The findings indicated that the miR-9875-PDCD6 pathway possessed fundamental effects "],"journal":["Virulence"],"pubmed_title":["miR-9875 functions in antiviral immunity by targeting PDCD6 in mud crab (<i>Scylla paramamosain</i>)."],"pmcid":["PMC7549984"],"funding_grant_id":["2018A030307044","2019KJ141","2017KQNCX072","41876152","31802341","NTF18001","GML2019ZD0606"],"pubmed_authors":["Ren X","Lin S","Li S","Kong T","Gong Y"],"additional_accession":[]},"is_claimable":false,"name":"miR-9875 functions in antiviral immunity by targeting PDCD6 in mud crab (<i>Scylla paramamosain</i>).","description":"Programmed cell death 6 (PDCD6) is a well-known apoptosis regulator that is involved in the immunity of mammals. However, the effects of miRNA-mediated regulation of PDCD6 expression on apoptosis and virus infection in organisms, especially in marine invertebrates, have not been extensively explored. In this study, PDCD6 of mud crab (<i>Scylla paramamosain</i>) (<i>Sp</i>-PDCD6) was characterized. The results showed that <i>Sp</i>-PDCD6 contains five EF-hands domains and could suppress virus infection <i>via</i> apoptosis promotion. It also presented that <i>Sp</i>-PDCD6 was directly targeted by miR-9875 <i>in vitro</i> and <i>in vivo</i>, miR-9875 served as a positive regulator during the virus invasion. The findings indicated that the miR-9875-PDCD6 pathway possessed fundamental effects ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-04T15:02:58.18Z","creation":"2020-11-07T10:03:31Z"},"accession":"S-EPMC7549984","cross_references":{"pubmed":["32597292"],"doi":["10.1080/21505594.2020.1787078"]}}