{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Birzer A"],"pubmed_abstract":["Herpes simplex virus type 1 (HSV-1) is a very common human pathogenic virus among the world's population. The lytic replication cycle of HSV-1 is, amongst others, characterized by a tripartite viral gene expression cascade, the assembly of nucleocapsids involving their subsequent nuclear egress, tegumentation, re-envelopment and the final release of progeny viral particles. During productive infection of a multitude of different cell types, HSV-1 generates not only infectious heavy (H-) particles, but also non-infectious light (L-) particles, lacking the capsid. In monocyte-derived mature dendritic cells (mDCs), HSV-1 causes a non-productive infection with the predominant release of L-particles. Until now, the generation and function of L-particles is not well understood, however, they are"],"journal":["Frontiers in microbiology"],"pagination":["1997"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7550753"],"repository":["biostudies-literature"],"pubmed_title":["Mass Spectrometric Characterization of HSV-1 L-Particles From Human Dendritic Cells and BHK21 Cells and Analysis of Their Functional Role."],"pmcid":["PMC7550753"],"pubmed_authors":["Kraner ME","Steinkasserer A","Hofmann J","Popella L","Birzer A","Heilingloh CS","Muhl-Zurbes P"],"additional_accession":[]},"is_claimable":false,"name":"Mass Spectrometric Characterization of HSV-1 L-Particles From Human Dendritic Cells and BHK21 Cells and Analysis of Their Functional Role.","description":"Herpes simplex virus type 1 (HSV-1) is a very common human pathogenic virus among the world's population. The lytic replication cycle of HSV-1 is, amongst others, characterized by a tripartite viral gene expression cascade, the assembly of nucleocapsids involving their subsequent nuclear egress, tegumentation, re-envelopment and the final release of progeny viral particles. During productive infection of a multitude of different cell types, HSV-1 generates not only infectious heavy (H-) particles, but also non-infectious light (L-) particles, lacking the capsid. In monocyte-derived mature dendritic cells (mDCs), HSV-1 causes a non-productive infection with the predominant release of L-particles. Until now, the generation and function of L-particles is not well understood, however, they are","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-04-07T21:48:54.792Z","creation":"2020-10-31T09:58:52Z"},"accession":"S-EPMC7550753","cross_references":{"pubmed":["33117298"],"doi":["10.3389/fmicb.2020.01997"]}}