{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(18)"],"submitter":["Plata E"],"pubmed_abstract":["To exploit the hydrolytic activity and high selectivity of immobilized lipase B from Candida antarctica on octyl agarose (CALB-OC) in the hydrolysis of triacetin and also to produce new value-added compounds from glycerol, this work describes a chemoenzymatic methodology for the synthesis of the new dimeric glycerol ester 3-((2,3-diacetoxypropanoyl)oxy)propane-1,2-diyl diacetate. According to this approach, triacetin was regioselectively hydrolyzed to 1,2-diacetin with CALB-OC. The diglyceride product was subsequently oxidized with pyridinium chlorochromate (PCC) and a dimeric ester was isolated as the only product. It was found that the medium acidity during the PCC treatment and a high 1,2-diacetin concentration favored the formation of the ester. The synthesized compounds were character"],"journal":["International journal of molecular sciences"],"pagination":["6501"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7555366"],"repository":["biostudies-literature"],"pubmed_title":["Chemoenzymatic Synthesis of the New 3-((2,3-Diacetoxypropanoyl)oxy)propane-1,2-diyl Diacetate Using Immobilized Lipase B from Candidaantarctica and Pyridinium Chlorochromate as an Oxidizing Agent."],"pmcid":["PMC7555366"],"pubmed_authors":["Ruiz J","Castillo JJ","Fernandez-Lafuente R","Plata E","Ortiz C","Ruiz M"],"additional_accession":[]},"is_claimable":false,"name":"Chemoenzymatic Synthesis of the New 3-((2,3-Diacetoxypropanoyl)oxy)propane-1,2-diyl Diacetate Using Immobilized Lipase B from Candidaantarctica and Pyridinium Chlorochromate as an Oxidizing Agent.","description":"To exploit the hydrolytic activity and high selectivity of immobilized lipase B from Candida antarctica on octyl agarose (CALB-OC) in the hydrolysis of triacetin and also to produce new value-added compounds from glycerol, this work describes a chemoenzymatic methodology for the synthesis of the new dimeric glycerol ester 3-((2,3-diacetoxypropanoyl)oxy)propane-1,2-diyl diacetate. According to this approach, triacetin was regioselectively hydrolyzed to 1,2-diacetin with CALB-OC. The diglyceride product was subsequently oxidized with pyridinium chlorochromate (PCC) and a dimeric ester was isolated as the only product. It was found that the medium acidity during the PCC treatment and a high 1,2-diacetin concentration favored the formation of the ester. The synthesized compounds were character","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2025-05-29T19:38:30.876Z","creation":"2025-05-29T19:38:30.876Z"},"accession":"S-EPMC7555366","cross_references":{"pubmed":["32899537"],"doi":["10.3390/ijms21186501"]}}