biostudies-literatureUnknown10Zuo YH<b>Objective:</b> To explore impact of <i>Candida</i> on the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) outcome. <b>Methods:</b> A retrospective, multi-center, case-control study was performed. Patients hospitalized for AECOPD in 25 centers during Jan 2011-Dec 2016 were enrolled. Data were collected, including demographic information, conditions during the stable phase of COPD, clinical characteristics of AECOPD, and follow-up information within 1 year after discharge. Univariate analysis and binary logistic regression were applied, and <i>p</i> < 0.05 was regarded as significant. <b>Results:</b> Totally 1,103 patients were analyzed, with 644 lower respiratory airway (LTR) <i>Candida</i> positive cases and 459 <i>Candida</i> negative controls. Long-term prognosis Frontiers in cellular and infection microbiology538005https://www.ebi.ac.uk/biostudies/studies/S-EPMC7561360biostudies-literature<i>Candida</i> in Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control Study.PMC7561360Zhang JBao ZYLi HYZuo YHChen QJHang JQZhang FYJin XYXu JFQu JMWang WQJie ZJLiu BGao XWSun HWang GFfalse<i>Candida</i> in Lower Respiratory Tract Increases the Frequency of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Case-Control Study.<b>Objective:</b> To explore impact of <i>Candida</i> on the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) outcome. <b>Methods:</b> A retrospective, multi-center, case-control study was performed. Patients hospitalized for AECOPD in 25 centers during Jan 2011-Dec 2016 were enrolled. Data were collected, including demographic information, conditions during the stable phase of COPD, clinical characteristics of AECOPD, and follow-up information within 1 year after discharge. Univariate analysis and binary logistic regression were applied, and <i>p</i> < 0.05 was regarded as significant. <b>Results:</b> Totally 1,103 patients were analyzed, with 644 lower respiratory airway (LTR) <i>Candida</i> positive cases and 459 <i>Candida</i> negative controls. Long-term prognosis 2020-01-01T00:00:00Z20202025-04-04T22:20:33.176Z2020-10-31T09:57:34ZS-EPMC75613603311772510.3389/fcimb.2020.538005