{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ohui K"],"funding":["Austrian Science Fund FWF"],"pagination":["E1336"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7564244"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(9)"],"pubmed_abstract":["Thiosemicarbazones continue to attract the interest of researchers as potential anticancer drugs. For example, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, or triapine, is the most well-known representative of this class of compounds that has entered multiple phase I and II clinical trials. Two new triapine derivatives HL1 and HL2 were prepared by condensation reactions of 2-pyridinamidrazone and S-methylisothiosemicarbazidium chloride with 3-N-(tert-butyloxycarbonyl) amino-pyridine-2-carboxaldehyde, followed by a Boc-deprotection procedure. Subsequent reaction of HL1 and HL2 with CuCl2·2H2O in 1:1 molar ratio in methanol produced the complexes [CuII(HL1)Cl2]·H2O (1·H2O) and [CuII(HL2)Cl2] (2). The reaction of HL2 with Fe(NO3)3∙9H2O in 2:1 molar ratio in the presence of triethylamin"],"journal":["Biomolecules"],"pubmed_title":["Triapine Derivatives Act as Copper Delivery Vehicles to Induce Deadly Metal Overload in Cancer Cells."],"pmcid":["PMC7564244"],"funding_grant_id":["P 28223","P28223-N34"],"pubmed_authors":["Popovic-Bijelic A","Giester G","Enyedy EA","Ohui K","Stafi R","Besleaga I","Babak MV","Stepanenko I","Vegh D","Posa V","Rapta P","Arion VB","Darvasiova D","Ang WH"],"additional_accession":[]},"is_claimable":false,"name":"Triapine Derivatives Act as Copper Delivery Vehicles to Induce Deadly Metal Overload in Cancer Cells.","description":"Thiosemicarbazones continue to attract the interest of researchers as potential anticancer drugs. For example, 3-aminopyridine-2-carboxaldehyde thiosemicarbazone, or triapine, is the most well-known representative of this class of compounds that has entered multiple phase I and II clinical trials. Two new triapine derivatives HL1 and HL2 were prepared by condensation reactions of 2-pyridinamidrazone and S-methylisothiosemicarbazidium chloride with 3-N-(tert-butyloxycarbonyl) amino-pyridine-2-carboxaldehyde, followed by a Boc-deprotection procedure. Subsequent reaction of HL1 and HL2 with CuCl2·2H2O in 1:1 molar ratio in methanol produced the complexes [CuII(HL1)Cl2]·H2O (1·H2O) and [CuII(HL2)Cl2] (2). The reaction of HL2 with Fe(NO3)3∙9H2O in 2:1 molar ratio in the presence of triethylamin","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2025-04-27T02:52:08.433Z","creation":"2020-10-30T08:35:51Z"},"accession":"S-EPMC7564244","cross_references":{"pubmed":["32961653"],"doi":["10.3390/biom10091336"]}}