{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hahn L"],"funding":["Deutsche Forschungsgemeinschaft","Interdisciplinary Centre for Clinical Research within the Faculty of Medicine at the RWTH Aachen University","Von-Behring-Röntgen-Stiftung"],"pagination":["E1949"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7564366"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(9)"],"pubmed_abstract":["The Th2 cytokine IL-13 is involved in biliary epithelial injury and liver fibrosis in patients as well as in animal models. The aim of this study was to investigate IL-13 as a therapeutic target during short term and chronic intrahepatic cholestasis in an <i>Abcb4-</i>knockout mouse model (<i>Abcb4</i><sup>-/-</sup>). Lack of IL-13 protected <i>Abcb4</i><sup>-/-</sup> mice transiently from cholestasis. This decrease in serum bile acids was accompanied by an enhanced excretion of bile acids and a normalization of fecal bile acid composition. In <i>Abcb4<sup>-/-</sup>/IL-13</i><sup>-/-</sup> double knockout mice, bacterial translocation to the liver was significantly reduced and the intestinal microbiome resembled the commensal composition in wild type animals. In addition, 52-week-old <i>Ab"],"journal":["Cells"],"pubmed_title":["IL-13 as Target to Reduce Cholestasis and Dysbiosis in <i>Abcb4</i> Knockout Mice."],"pmcid":["PMC7564366"],"funding_grant_id":["SFB1021 Z02","KFO309 Z01","KFO 217","RO 957/10-1","project O3-1","RO 3714/4","SFB/TRR57, projects P13 and Q3","60-0002","SFB-TR84 project B08","RO 957/11"],"pubmed_authors":["Mayatepek E","Baier A","Drebber U","Weiskirchen R","Weigel M","Helmrich N","Windhorst A","Roeb E","Domann E","Rath T","Hahn L","Olejniczak S","Schmidt N","Ewers C","Churin Y","Hain T","Mollenkopf HJ","Roderfeld M","Herebian D","Steinhoff U","Wirtz S"],"additional_accession":[]},"is_claimable":false,"name":"IL-13 as Target to Reduce Cholestasis and Dysbiosis in <i>Abcb4</i> Knockout Mice.","description":"The Th2 cytokine IL-13 is involved in biliary epithelial injury and liver fibrosis in patients as well as in animal models. The aim of this study was to investigate IL-13 as a therapeutic target during short term and chronic intrahepatic cholestasis in an <i>Abcb4-</i>knockout mouse model (<i>Abcb4</i><sup>-/-</sup>). Lack of IL-13 protected <i>Abcb4</i><sup>-/-</sup> mice transiently from cholestasis. This decrease in serum bile acids was accompanied by an enhanced excretion of bile acids and a normalization of fecal bile acid composition. In <i>Abcb4<sup>-/-</sup>/IL-13</i><sup>-/-</sup> double knockout mice, bacterial translocation to the liver was significantly reduced and the intestinal microbiome resembled the commensal composition in wild type animals. In addition, 52-week-old <i>Ab","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2026-04-14T23:20:28.552Z","creation":"2020-10-30T08:35:14Z"},"accession":"S-EPMC7564366","cross_references":{"pubmed":["32846954"],"doi":["10.3390/cells9091949"]}}