{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shaath H"],"funding":["Qatar Biomedical Research institute"],"pagination":["E260"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7564677"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(9)"],"pubmed_abstract":["The continuous and rapid emergence of new viral strains calls for a better understanding of the fundamental changes occurring within the host cell upon viral infection. In this study, we analyzed RNA-seq transcriptome data from Calu-3 human lung epithelial cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared to five other viruses namely, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome (SARS-MERS), influenzavirus A (FLUA), influenzavirus B (FLUB), and rhinovirus (RHINO) compared to mock-infected cells and characterized their coding and noncoding RNA transcriptional portraits. The induction of interferon, inflammatory, and immune response was a hallmark of SARS-CoV-2 infection. Comprehensive bioinformatics reveal"],"journal":["Biology"],"pubmed_title":["Computational and Transcriptome Analyses Revealed Preferential Induction of Chemotaxis and Lipid Synthesis by SARS-CoV-2."],"pmcid":["PMC7564677"],"funding_grant_id":["QB13"],"pubmed_authors":["Alajez NM","Shaath H"],"additional_accession":[]},"is_claimable":false,"name":"Computational and Transcriptome Analyses Revealed Preferential Induction of Chemotaxis and Lipid Synthesis by SARS-CoV-2.","description":"The continuous and rapid emergence of new viral strains calls for a better understanding of the fundamental changes occurring within the host cell upon viral infection. In this study, we analyzed RNA-seq transcriptome data from Calu-3 human lung epithelial cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared to five other viruses namely, severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome (SARS-MERS), influenzavirus A (FLUA), influenzavirus B (FLUB), and rhinovirus (RHINO) compared to mock-infected cells and characterized their coding and noncoding RNA transcriptional portraits. The induction of interferon, inflammatory, and immune response was a hallmark of SARS-CoV-2 infection. Comprehensive bioinformatics reveal","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2026-04-08T00:39:04.489Z","creation":"2020-11-01T08:24:03Z"},"accession":"S-EPMC7564677","cross_references":{"pubmed":["32882823"],"doi":["10.3390/biology9090260"]}}