{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["61(12)"],"submitter":["Yuan J"],"pubmed_abstract":["<h4>Purpose</h4>The coronavirus disease 2019 (COVID-19) pandemic severely challenges public health and necessitates the need for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection and propagation. The aim of this study was to investigate key factors for cellular susceptibility to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection in the ocular surface cells.<h4>Methods</h4>We combined co-expression and SARS-CoV-2 interactome network to predict key genes at COVID-19 in ocular infection based on the premise that genes underlying a disease are often functionally related and functionally related genes are often co-expressed.<h4>Results</h4>The co-expression network was constructed by mapping the well-known angiotensin"],"journal":["Investigative ophthalmology & visual science"],"pagination":["13"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7571327"],"repository":["biostudies-literature"],"pubmed_title":["Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19."],"pmcid":["PMC7571327"],"pubmed_authors":["Qu J","Su J","Xue Z","Yuan J","Fan D"],"additional_accession":[]},"is_claimable":false,"name":"Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19.","description":"<h4>Purpose</h4>The coronavirus disease 2019 (COVID-19) pandemic severely challenges public health and necessitates the need for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection and propagation. The aim of this study was to investigate key factors for cellular susceptibility to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection in the ocular surface cells.<h4>Methods</h4>We combined co-expression and SARS-CoV-2 interactome network to predict key genes at COVID-19 in ocular infection based on the premise that genes underlying a disease are often functionally related and functionally related genes are often co-expressed.<h4>Results</h4>The co-expression network was constructed by mapping the well-known angiotensin","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-19T01:22:36.925Z","creation":"2020-11-07T10:01:50Z"},"accession":"S-EPMC7571327","cross_references":{"pubmed":["33049061"],"doi":["10.1167/iovs.61.12.13"]}}