biostudies-literatureUnknown61(12)Yuan J<h4>Purpose</h4>The coronavirus disease 2019 (COVID-19) pandemic severely challenges public health and necessitates the need for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection and propagation. The aim of this study was to investigate key factors for cellular susceptibility to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection in the ocular surface cells.<h4>Methods</h4>We combined co-expression and SARS-CoV-2 interactome network to predict key genes at COVID-19 in ocular infection based on the premise that genes underlying a disease are often functionally related and functionally related genes are often co-expressed.<h4>Results</h4>The co-expression network was constructed by mapping the well-known angiotensinInvestigative ophthalmology & visual science13https://www.ebi.ac.uk/biostudies/studies/S-EPMC7571327biostudies-literatureCo-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19.PMC7571327Qu JSu JXue ZYuan JFan DfalseCo-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19.<h4>Purpose</h4>The coronavirus disease 2019 (COVID-19) pandemic severely challenges public health and necessitates the need for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection and propagation. The aim of this study was to investigate key factors for cellular susceptibility to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection in the ocular surface cells.<h4>Methods</h4>We combined co-expression and SARS-CoV-2 interactome network to predict key genes at COVID-19 in ocular infection based on the premise that genes underlying a disease are often functionally related and functionally related genes are often co-expressed.<h4>Results</h4>The co-expression network was constructed by mapping the well-known angiotensin2020-01-01T00:00:00Z2020 Oct2025-04-19T01:22:36.925Z2020-11-07T10:01:50ZS-EPMC75713273304906110.1167/iovs.61.12.13