{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(4)"],"submitter":["Kim BJ"],"pubmed_abstract":["<h4>Background</h4>Recent studies have demonstrated that angiotensin receptor neprilysin inhibitors (ARNIs) can reverse the cardiac remodeling effects that occur in heart failure with reduced ejection fraction (HFrEF). These studies have also suggested that ARNIs have favorable effects on ventricular dyssynchrony. We assessed the changes in QRS duration associated with ARNIs in patients with HFrEF.<h4>Methods</h4>We retrospectively investigated patients with HFrEF (defined by a left ventricular ejection fraction [LVEF] ≤ 35%) who were treated with ARNIs for at least six months. We divided the patients into QRS shortening and non-QRS shortening groups according to their electrocardiogram (ECG) findings. We also compared changes in echocardiographic parameters between the groups.<h4>Results<"],"journal":["Journal of cardiovascular imaging"],"pagination":["244-253"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7572265"],"repository":["biostudies-literature"],"pubmed_title":["Changes in QRS Duration Are Associated with a Therapeutic Response to Sacubitril-valsartan in Heart Failure with Reduced Ejection Fraction."],"pmcid":["PMC7572265"],"pubmed_authors":["Cha TJ","Park HS","Heo JH","Im SI","Cho KI","Kim HS","Kim BJ"],"additional_accession":[]},"is_claimable":false,"name":"Changes in QRS Duration Are Associated with a Therapeutic Response to Sacubitril-valsartan in Heart Failure with Reduced Ejection Fraction.","description":"<h4>Background</h4>Recent studies have demonstrated that angiotensin receptor neprilysin inhibitors (ARNIs) can reverse the cardiac remodeling effects that occur in heart failure with reduced ejection fraction (HFrEF). These studies have also suggested that ARNIs have favorable effects on ventricular dyssynchrony. We assessed the changes in QRS duration associated with ARNIs in patients with HFrEF.<h4>Methods</h4>We retrospectively investigated patients with HFrEF (defined by a left ventricular ejection fraction [LVEF] ≤ 35%) who were treated with ARNIs for at least six months. We divided the patients into QRS shortening and non-QRS shortening groups according to their electrocardiogram (ECG) findings. We also compared changes in echocardiographic parameters between the groups.<h4>Results<","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-22T14:39:34.372Z","creation":"2020-10-29T14:51:02Z"},"accession":"S-EPMC7572265","cross_references":{"pubmed":["33086439"],"doi":["10.4250/jcvi.2020.0025"]}}