{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chiu YL"],"funding":["Ministry of Science and Technology, Taiwan"],"pagination":["31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7574244"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17"],"pubmed_abstract":["<h4>Background</h4>Type 2 diabetes is an important challenge given the worldwide epidemic and is the most important cause of end-stage renal disease (ESRD) in developed countries. It is known that patients with ESRD and advanced renal failure suffer from immunosenescence and premature T cell aging, but whether such changes develop in patients with less severe chronic kidney disease (CKD) is unclear.<h4>Method</h4>523 adult patients with type 2 diabetes were recruited for this study. Demographic data and clinical information were obtained from medical chart review. Immunosenescence, or aging of the immune system was assessed by staining freshly-obtained peripheral blood with immunophenotyping panels and analyzing cells using multicolor flow cytometry.<h4>Result</h4>Consistent with previousl"],"journal":["Immunity & ageing : I & A"],"pubmed_title":["Emergence of T cell immunosenescence in diabetic chronic kidney disease."],"pmcid":["PMC7574244"],"funding_grant_id":["106-2314-B-418-008-MY3"],"pubmed_authors":["Chiu YL","Pan SY","Peng YS","Ting TT","Chen IY","Tsai WC","Hung RW","Shu KH","Jiang JY","Chuang YF","Yang FJ"],"additional_accession":[]},"is_claimable":false,"name":"Emergence of T cell immunosenescence in diabetic chronic kidney disease.","description":"<h4>Background</h4>Type 2 diabetes is an important challenge given the worldwide epidemic and is the most important cause of end-stage renal disease (ESRD) in developed countries. It is known that patients with ESRD and advanced renal failure suffer from immunosenescence and premature T cell aging, but whether such changes develop in patients with less severe chronic kidney disease (CKD) is unclear.<h4>Method</h4>523 adult patients with type 2 diabetes were recruited for this study. Demographic data and clinical information were obtained from medical chart review. Immunosenescence, or aging of the immune system was assessed by staining freshly-obtained peripheral blood with immunophenotyping panels and analyzing cells using multicolor flow cytometry.<h4>Result</h4>Consistent with previousl","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-26T14:47:29.374Z","creation":"2020-10-29T12:36:49Z"},"accession":"S-EPMC7574244","cross_references":{"pubmed":["33088331"],"doi":["10.1186/s12979-020-00200-1"]}}