biostudies-literatureChiu YLMinistry of Science and Technology, Taiwan31https://www.ebi.ac.uk/biostudies/studies/S-EPMC7574244biostudies-literatureUnknown17<h4>Background</h4>Type 2 diabetes is an important challenge given the worldwide epidemic and is the most important cause of end-stage renal disease (ESRD) in developed countries. It is known that patients with ESRD and advanced renal failure suffer from immunosenescence and premature T cell aging, but whether such changes develop in patients with less severe chronic kidney disease (CKD) is unclear.<h4>Method</h4>523 adult patients with type 2 diabetes were recruited for this study. Demographic data and clinical information were obtained from medical chart review. Immunosenescence, or aging of the immune system was assessed by staining freshly-obtained peripheral blood with immunophenotyping panels and analyzing cells using multicolor flow cytometry.<h4>Result</h4>Consistent with previouslImmunity & ageing : I & AEmergence of T cell immunosenescence in diabetic chronic kidney disease.PMC7574244106-2314-B-418-008-MY3Chiu YLPan SYPeng YSTing TTChen IYTsai WCHung RWShu KHJiang JYChuang YFYang FJfalseEmergence of T cell immunosenescence in diabetic chronic kidney disease.<h4>Background</h4>Type 2 diabetes is an important challenge given the worldwide epidemic and is the most important cause of end-stage renal disease (ESRD) in developed countries. It is known that patients with ESRD and advanced renal failure suffer from immunosenescence and premature T cell aging, but whether such changes develop in patients with less severe chronic kidney disease (CKD) is unclear.<h4>Method</h4>523 adult patients with type 2 diabetes were recruited for this study. Demographic data and clinical information were obtained from medical chart review. Immunosenescence, or aging of the immune system was assessed by staining freshly-obtained peripheral blood with immunophenotyping panels and analyzing cells using multicolor flow cytometry.<h4>Result</h4>Consistent with previousl2020-01-01T00:00:00Z20202025-04-26T14:47:29.374Z2020-10-29T12:36:49ZS-EPMC75742443308833110.1186/s12979-020-00200-1