{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Kim BS"],"funding":["National Research Foundation of Korea","Seoul National University"],"pubmed_abstract":["Polyphenols can trigger immunity that activates intracellular anti-inflammatory signaling and prevents external infections. In this study, we report the fabrication of chitosan-based hydrogels with epigallocatechin gallate (EGCG) using enzyme-mediated one-pot synthesis. The tyrosinase-mediated oxidative reaction of the phenolic rings of EGCG with the primary amines on chitosan results in stable EGCG-chitosan hydrogels. The EGCG concentrations contributed to the cross-linking density and physical properties of EGCG-chitosan hydrogels. Furthermore, EGCG-chitosan hydrogels maintained intrinsic properties such as antibacterial and antioxidant effects. When endotoxin-activated RAW 264.7 macrophage cells were cultured with EGCG-chitosan hydrogels, the hydrogels reduced the inflammatory response "],"journal":["Materials today. Bio"],"pagination":["100079"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7575804"],"repository":["biostudies-literature"],"pubmed_title":["Enzyme-mediated one-pot synthesis of hydrogel with the polyphenol cross-linker for skin regeneration."],"pmcid":["PMC7575804"],"pubmed_authors":["Kim SH","Kim BG","An YH","So KH","Kim BS","Hwang NS","Kim K"],"additional_accession":[]},"is_claimable":false,"name":"Enzyme-mediated one-pot synthesis of hydrogel with the polyphenol cross-linker for skin regeneration.","description":"Polyphenols can trigger immunity that activates intracellular anti-inflammatory signaling and prevents external infections. In this study, we report the fabrication of chitosan-based hydrogels with epigallocatechin gallate (EGCG) using enzyme-mediated one-pot synthesis. The tyrosinase-mediated oxidative reaction of the phenolic rings of EGCG with the primary amines on chitosan results in stable EGCG-chitosan hydrogels. The EGCG concentrations contributed to the cross-linking density and physical properties of EGCG-chitosan hydrogels. Furthermore, EGCG-chitosan hydrogels maintained intrinsic properties such as antibacterial and antioxidant effects. When endotoxin-activated RAW 264.7 macrophage cells were cultured with EGCG-chitosan hydrogels, the hydrogels reduced the inflammatory response ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Sep","modification":"2026-05-07T19:23:11.159Z","creation":"2026-04-07T23:13:32.568Z"},"accession":"S-EPMC7575804","cross_references":{"pubmed":["33103105"],"doi":["10.1016/j.mtbio.2020.100079"]}}