{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Nakano R"],"pubmed_abstract":["The pro-inflammatory cytokine interleukin 1<i>β</i> (IL-1<i>β</i>) induces the synthesis of prostaglandin E<sub>2</sub> by upregulating cyclooxygenase-2 (COX-2) in the synovial tissue of individuals with autoimmune diseases, such as rheumatoid arthritis (RA). IL-1<i>β</i>-mediated stimulation of NF-<i>κ</i>B and MAPK signaling is important for the pathogenesis of RA; however, crosstalk(s) between NF-<i>κ</i>B and MAPK signaling remains to be understood. In this study, we established a model for IL-1<i>β</i>-induced synovitis and investigated the role of NF-<i>κ</i>B and MAPK signaling in synovitis. We observed an increase in the mRNA and protein levels of COX-2 and prostaglandin E<sub>2</sub> release in cells treated with IL-1<i>β</i>. NF-<i>κ</i>B and ERK1/2 inhibitors significantly reduc"],"journal":["Frontiers in immunology"],"pagination":["579266"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7576893"],"repository":["biostudies-literature"],"pubmed_title":["Non-Transcriptional and Translational Function of Canonical NF-<i>κ</i>B Signaling in Activating ERK1/2 in IL-1<i>β</i>-Induced COX-2 Expression in Synovial Fibroblasts."],"pmcid":["PMC7576893"],"pubmed_authors":["Kitanaka T","Konno T","Yamazaki J","Nakayama T","Nakano R","Namba S","Suwabe Y","Sugiya H","Kitanaka N"],"additional_accession":[]},"is_claimable":false,"name":"Non-Transcriptional and Translational Function of Canonical NF-<i>κ</i>B Signaling in Activating ERK1/2 in IL-1<i>β</i>-Induced COX-2 Expression in Synovial Fibroblasts.","description":"The pro-inflammatory cytokine interleukin 1<i>β</i> (IL-1<i>β</i>) induces the synthesis of prostaglandin E<sub>2</sub> by upregulating cyclooxygenase-2 (COX-2) in the synovial tissue of individuals with autoimmune diseases, such as rheumatoid arthritis (RA). IL-1<i>β</i>-mediated stimulation of NF-<i>κ</i>B and MAPK signaling is important for the pathogenesis of RA; however, crosstalk(s) between NF-<i>κ</i>B and MAPK signaling remains to be understood. In this study, we established a model for IL-1<i>β</i>-induced synovitis and investigated the role of NF-<i>κ</i>B and MAPK signaling in synovitis. We observed an increase in the mRNA and protein levels of COX-2 and prostaglandin E<sub>2</sub> release in cells treated with IL-1<i>β</i>. NF-<i>κ</i>B and ERK1/2 inhibitors significantly reduc","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-04-14T23:19:29.903Z","creation":"2020-10-30T08:34:43Z"},"accession":"S-EPMC7576893","cross_references":{"pubmed":["33117381"],"doi":["10.3389/fimmu.2020.579266"]}}