{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Richardson M"],"funding":["NIDCR NIH HHS","National Cancer Institute","National Institute of Dental and Craniofacial Research","NCI NIH HHS","National Science Foundation"],"pagination":["1-13"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7577115"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["<i>Fusobacterium nucleatum</i> is a Gram-negative oral commensal anaerobe which has been increasingly implicated in various gastrointestinal (GI) disorders, including inflammatory bowel disease, appendicitis, GI cancers. The oral cavity harbors a diverse group of <i>Fusobacterium</i>, and it is postulated that <i>F. nucleatum</i> in the GI tract originate from the mouth. It is not known, however, if all oral <i>Fusobacterium</i> translocate to the GI sites with equal efficiencies. Therefore, we amplified 16S rRNA genes of <i>F. nucleatum</i> and <i>F. periodonticum</i>, two closely related oral species from matched saliva, gastric aspirates, and colon or ileal pouch aspirates of three patients with inflammatory bowel disease (IBD) and three healthy controls, and saliva alone from seven pat"],"journal":["Gut microbes"],"pubmed_title":["Analysis of 16S rRNA genes reveals reduced Fusobacterial community diversity when translocating from saliva to GI sites."],"pmcid":["PMC7577115"],"funding_grant_id":["R01 DE014924","R01 CA192111","DE014924","DGE-1644869","R01 DE023332","DE023332","R01 DE029532","CA192111"],"pubmed_authors":["Taylor JA","Richardson M","Ren J","Rubinstein MR","Shen B","Friedman RA","Han YW"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of 16S rRNA genes reveals reduced Fusobacterial community diversity when translocating from saliva to GI sites.","description":"<i>Fusobacterium nucleatum</i> is a Gram-negative oral commensal anaerobe which has been increasingly implicated in various gastrointestinal (GI) disorders, including inflammatory bowel disease, appendicitis, GI cancers. The oral cavity harbors a diverse group of <i>Fusobacterium</i>, and it is postulated that <i>F. nucleatum</i> in the GI tract originate from the mouth. It is not known, however, if all oral <i>Fusobacterium</i> translocate to the GI sites with equal efficiencies. Therefore, we amplified 16S rRNA genes of <i>F. nucleatum</i> and <i>F. periodonticum</i>, two closely related oral species from matched saliva, gastric aspirates, and colon or ileal pouch aspirates of three patients with inflammatory bowel disease (IBD) and three healthy controls, and saliva alone from seven pat","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2026-04-14T03:19:44.04Z","creation":"2025-05-31T23:52:26.983Z"},"accession":"S-EPMC7577115","cross_references":{"pubmed":["33054632"],"doi":["10.1080/19490976.2020.1814120"]}}