{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Altman MC"],"funding":["BLRD VA","NCATS NIH HHS","NIAID NIH HHS","National Institutes of Health","NIH HHS","NIGMS NIH HHS","US Department of Veterans Affairs"],"pagination":["1332-1344"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7577409"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["145(5)"],"pubmed_abstract":["Over the past decade, there have been substantial advances in our understanding about how viral infections regulate asthma. Important lessons have been learned from birth cohort studies examining viral infections and subsequent asthma and from understanding the relationships between host genetics and viral infections, the contributions of respiratory viral infections to patterns of immune development, the impact of environmental exposure on the severity of viral infections, and how the viral genome influences host immune responses to viral infections. Further, there has been major progress in our knowledge about how bacteria regulate host immune responses in asthma pathogenesis. In this article, we also examine the dynamics of bacterial colonization of the respiratory tract during viral upper respiratory tract infection, in addition to the relationship of the gut and respiratory microbiomes with respiratory viral infections. Finally, we focus on potential interventions that could decrease virus-induced wheezing and asthma. There are emerging therapeutic options to decrease the severity of wheezing exacerbations caused by respiratory viral infections. Primary prevention is a major goal, and a strategy toward this end is considered."],"journal":["The Journal of allergy and clinical immunology"],"pubmed_title":["Evolving concepts in how viruses impact asthma: A Work Group Report of the Microbes in Allergy Committee of the American Academy of Allergy, Asthma & Immunology."],"pmcid":["PMC7577409"],"funding_grant_id":["R21AI145397","U19AI104317","K08 AI121345","UL1 TR003107","UL1 TR001449","KL2 TR000063","I01BX004299","R01AI124456","T32 AI007496","T32AI007496","UM1 AI114271","U01 AI100799","R01 AI145265","U19AI095227","R21 AI145397","UM1AI114271","K23 AI135094","UG3/UH3OD023282","UG3 OD023282","UH3 OD023282","U19 AI095227","I01 BX004299","K08AI1211345","U19 AI104317","L40 AI096442","R01 AI124456","R01AI145265","U01AI100799","P20 GM121293"],"pubmed_authors":["McWilliams LM","Peebles RS","Kloepfer K","Kennedy JL","Nance C","Gern JE","Muehling L","Jackson DJ","Ciaccio C","Heymann PW","Lemanske RF","Beigelman A","Altman MC"],"additional_accession":[]},"is_claimable":false,"name":"Evolving concepts in how viruses impact asthma: A Work Group Report of the Microbes in Allergy Committee of the American Academy of Allergy, Asthma & Immunology.","description":"Over the past decade, there have been substantial advances in our understanding about how viral infections regulate asthma. Important lessons have been learned from birth cohort studies examining viral infections and subsequent asthma and from understanding the relationships between host genetics and viral infections, the contributions of respiratory viral infections to patterns of immune development, the impact of environmental exposure on the severity of viral infections, and how the viral genome influences host immune responses to viral infections. Further, there has been major progress in our knowledge about how bacteria regulate host immune responses in asthma pathogenesis. In this article, we also examine the dynamics of bacterial colonization of the respiratory tract during viral upper respiratory tract infection, in addition to the relationship of the gut and respiratory microbiomes with respiratory viral infections. Finally, we focus on potential interventions that could decrease virus-induced wheezing and asthma. There are emerging therapeutic options to decrease the severity of wheezing exacerbations caused by respiratory viral infections. Primary prevention is a major goal, and a strategy toward this end is considered.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2024-02-15T19:43:38.55Z","creation":"2022-02-10T08:17:53.015Z"},"accession":"S-EPMC7577409","cross_references":{"pubmed":["31926183"],"doi":["10.1016/j.jaci.2019.12.904"]}}