{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Engmann AK"],"funding":["Swiss National Science Foundation","European Research Council","Christopher and Dana Reeve Foundation"],"pagination":["8292-8305"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7577599"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(43)"],"pubmed_abstract":["Traditionally, the brainstem has been seen as hardwired and poorly capable of plastic adaptations following spinal cord injury (SCI). Data acquired over the past decades, however, suggest differently: following SCI in various animal models (lamprey, chick, rodents, nonhuman primates), different forms of spontaneous anatomic plasticity of reticulospinal projections, many of them originating from the gigantocellular reticular nucleus (NRG), have been observed. In line with these anatomic observations, animals and humans with incomplete SCI often show various degrees of spontaneous motor recovery of hindlimb/leg function. Here, we investigated the functional relevance of two different modes of reticulospinal fiber growth after cervical hemisection, local rewiring of axotomized projections at "],"journal":["The Journal of neuroscience : the official journal of the Society for Neuroscience"],"pubmed_title":["The Gigantocellular Reticular Nucleus Plays a Significant Role in Locomotor Recovery after Incomplete Spinal Cord Injury."],"pmcid":["PMC7577599"],"funding_grant_id":["294115","3100A0-1222527-2","294115 NOGORISE"],"pubmed_authors":["Engmann AK","Pfyffer D","Bizzozzero F","Imobersteg S","Schneider R","Wieckhorst M","Schneider MP","Schwab ME","Hofer AS"],"additional_accession":[]},"is_claimable":false,"name":"The Gigantocellular Reticular Nucleus Plays a Significant Role in Locomotor Recovery after Incomplete Spinal Cord Injury.","description":"Traditionally, the brainstem has been seen as hardwired and poorly capable of plastic adaptations following spinal cord injury (SCI). Data acquired over the past decades, however, suggest differently: following SCI in various animal models (lamprey, chick, rodents, nonhuman primates), different forms of spontaneous anatomic plasticity of reticulospinal projections, many of them originating from the gigantocellular reticular nucleus (NRG), have been observed. In line with these anatomic observations, animals and humans with incomplete SCI often show various degrees of spontaneous motor recovery of hindlimb/leg function. Here, we investigated the functional relevance of two different modes of reticulospinal fiber growth after cervical hemisection, local rewiring of axotomized projections at ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2026-07-09T11:17:29.959Z","creation":"2026-07-09T10:40:16.48Z"},"accession":"S-EPMC7577599","cross_references":{"pubmed":["32978289"],"doi":["10.1523/JNEUROSCI.0474-20.2020","10.1523/jneurosci.0474-20.2020"]}}