{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kozlova EV"],"funding":["Tobacco-Related Disease Research Program","Sigma Xi","NIDDK NIH HHS","NIEHS NIH HHS","University of California Institute for Mexico and the United States","UCR Committee on Research","National Institutes of Health","Department of Education STEM-HSI","NIH HHS","UCR Office of Undergraduate Education Mini-Grant","NIGMS NIH HHS"],"pagination":["18102"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7582149"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["Polybrominated diphenyl ethers (PBDEs) are brominated flame retardant chemicals and environmental contaminants with endocrine-disrupting properties that are associated with diabetes and metabolic syndrome in humans. However, their diabetogenic actions are not completely characterized or understood. In this study, we investigated the effects of DE-71, a commercial penta-mixture of PBDEs, on glucoregulatory parameters in a perinatal exposure model using female C57Bl/6 mice. Results from in vivo glucose and insulin tolerance tests and ex vivo analyses revealed fasting hyperglycemia, glucose intolerance, reduced sensitivity and delayed glucose clearance after insulin challenge, decreased thermogenic brown adipose tissue mass, and exaggerated hepatic endocannabinoid tone in F1 offspring exposed"],"journal":["Scientific reports"],"pubmed_title":["Maternal transfer of environmentally relevant polybrominated diphenyl ethers (PBDEs) produces a diabetic phenotype and disrupts glucoregulatory hormones and hepatic endocannabinoids in adult mouse female offspring."],"pmcid":["PMC7582149"],"funding_grant_id":["T29KT0232","T34 GM062756","R56 DK119498","R01 ES016099","R01 DK119498","DK119498","L30 DK114978"],"pubmed_authors":["Bishay AE","Chinthirla BD","Basappa KR","Curras-Collazo MC","Stapleton HM","DiPatrizio NV","Argueta DA","Gonzalez GM","Krum JM","Kozlova EV","Phillips AL","Perez PA","Carrillo V"],"additional_accession":[]},"is_claimable":false,"name":"Maternal transfer of environmentally relevant polybrominated diphenyl ethers (PBDEs) produces a diabetic phenotype and disrupts glucoregulatory hormones and hepatic endocannabinoids in adult mouse female offspring.","description":"Polybrominated diphenyl ethers (PBDEs) are brominated flame retardant chemicals and environmental contaminants with endocrine-disrupting properties that are associated with diabetes and metabolic syndrome in humans. However, their diabetogenic actions are not completely characterized or understood. In this study, we investigated the effects of DE-71, a commercial penta-mixture of PBDEs, on glucoregulatory parameters in a perinatal exposure model using female C57Bl/6 mice. Results from in vivo glucose and insulin tolerance tests and ex vivo analyses revealed fasting hyperglycemia, glucose intolerance, reduced sensitivity and delayed glucose clearance after insulin challenge, decreased thermogenic brown adipose tissue mass, and exaggerated hepatic endocannabinoid tone in F1 offspring exposed","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-26T14:50:26.194Z","creation":"2020-10-29T14:50:41Z"},"accession":"S-EPMC7582149","cross_references":{"pubmed":["33093533"],"doi":["10.1038/s41598-020-74853-9"]}}