biostudies-literatureYang JFKey Research and Development Plan of Hunan ProvinceNational Key Research and Development Programme of China1879-1889https://www.ebi.ac.uk/biostudies/studies/S-EPMC7589246biostudies-literatureUnknown37(11)<h4>Aims</h4>To examine the association between 24 literature-based single nucleotide polymorphisms and diabetic kidney disease in Chinese people with type 2 diabetes.<h4>Methods and results</h4>Twenty-four candidate diabetic kidney disease-susceptible single nucleotide polymorphisms were genotyped in 208 participants with type 2 diabetes and diabetic kidney disease and 200 participants with type 2 diabetes without diabetic kidney disease (case and control groups, respectively), together with 206 healthy participants using MassARRAY. Rs11643718 in the SLC12A3 gene was associated with diabetic kidney disease in the recessive model after adjusting for confounding factors, such as age and gender (adjusted odds ratio 2.056, 95% CI 1.120-3.776; P = 0.020). Meta-analyses further confirmed the asDiabetic medicine : a journal of the British Diabetic AssociationThe single nucleotide polymorphism rs11643718 in SLC12A3 is associated with the development of diabetic kidney disease in Chinese people with type 2 diabetes.PMC75892462016JC20612018YFC13140022016YFC1305501Zhou ZGWang NSFan YXiao YYang MLiu SPXiong XFXiong SLi LLi CRJiang NSun LZeng LFHan YCYang JFWei LZhao HfalseThe single nucleotide polymorphism rs11643718 in SLC12A3 is associated with the development of diabetic kidney disease in Chinese people with type 2 diabetes.<h4>Aims</h4>To examine the association between 24 literature-based single nucleotide polymorphisms and diabetic kidney disease in Chinese people with type 2 diabetes.<h4>Methods and results</h4>Twenty-four candidate diabetic kidney disease-susceptible single nucleotide polymorphisms were genotyped in 208 participants with type 2 diabetes and diabetic kidney disease and 200 participants with type 2 diabetes without diabetic kidney disease (case and control groups, respectively), together with 206 healthy participants using MassARRAY. Rs11643718 in the SLC12A3 gene was associated with diabetic kidney disease in the recessive model after adjusting for confounding factors, such as age and gender (adjusted odds ratio 2.056, 95% CI 1.120-3.776; P = 0.020). Meta-analyses further confirmed the as2020-01-01T00:00:00Z2020 Nov2026-05-03T09:22:45.17Z2020-11-03T08:04:44ZS-EPMC75892463263486110.1111/dme.14364