biostudies-literatureFink ELNational Institute of Neurological Disorders and StrokeNICHD NIH HHSNINDS NIH HHSe039323https://www.ebi.ac.uk/biostudies/studies/S-EPMC7592297biostudies-literatureUnknown10(10)<h4>Introduction</h4>Blood and imaging biomarkers show promise in prognosticating outcomes after paediatric cardiac arrest in pilot studies. We describe the methods and early recruitment challenges and solutions for an ongoing multicentre (n=14) observational trial, Personalising Outcomes following Child Cardiac Arrest to validate clinical, blood and imaging biomarkers individually and together in a clinically relevant panel.<h4>Methods and analysis</h4>Children (n=164) between 48 hours and 17 years of age who receive chest compressions irrespective of provider, duration, or event location and are admitted to an intensive care unit are eligible. Blood samples will be taken on days 1-3 for the measurement of brain-focused biomarkers analysed to predict the outcome. Clinically indicated and BMJ openPersonalising Outcomes after Child Cardiac Arrest (POCCA): design and recruitment challenges of a multicentre, observational study.PMC7592297R01 NS096714K23 HD099309Hlivka LShad SFink ELHaller TNewth CJRubin PChung MGHensley JLittle MBrown DSiegel KSierra YFriess SClark RSBPatel NMeyer MTFrank AElmer JBluml SDuval-Arnould JPiantino JHunt EProdell JWinters MTutundzic ASubramanian SSzypulski SDyar BSteele LKevin Van BSBurrows BWalson KVemulapalli ABalakrishnan BKwok JMurkowski KBayir HBerger RGrosskreuz RWillyerd ARichardson MGHession DBates CClark RKochanek PJones RFabio ADesai BDoughty LPOCCA InvestigatorsRich DRyan LWallace JPineda JTomanio EBeers SRFeldman KCabrales AFabio TWenger JParikh DKochanek PMMelvin PDay TWolfe ADiddle JBenken LMaloney DSiems AMishler LWisnowski JBarganier LTopjian AMaddux ASmith LPatregnani JSmith KRobinson TBeers SAdewale RKasch MKeys CPanigrahy AfalsePersonalising Outcomes after Child Cardiac Arrest (POCCA): design and recruitment challenges of a multicentre, observational study.<h4>Introduction</h4>Blood and imaging biomarkers show promise in prognosticating outcomes after paediatric cardiac arrest in pilot studies. We describe the methods and early recruitment challenges and solutions for an ongoing multicentre (n=14) observational trial, Personalising Outcomes following Child Cardiac Arrest to validate clinical, blood and imaging biomarkers individually and together in a clinically relevant panel.<h4>Methods and analysis</h4>Children (n=164) between 48 hours and 17 years of age who receive chest compressions irrespective of provider, duration, or event location and are admitted to an intensive care unit are eligible. Blood samples will be taken on days 1-3 for the measurement of brain-focused biomarkers analysed to predict the outcome. Clinically indicated and 2020-01-01T00:00:00Z2020 Oct2026-05-07T17:40:38.752Z2025-05-29T20:01:38.891ZS-EPMC75922973310966710.1136/bmjopen-2020-039323