{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["110(11-12)"],"submitter":["Kim D"],"pubmed_abstract":["<h4>Introduction</h4>Synchronous and pulsatile neural activation of kisspeptin neurons in the arcuate nucleus (ARN) are important components of the gonadotropin-releasing hormone pulse generator, the final common pathway for central regulation of mammalian reproduction. However, whether ARN kisspeptin neurons can intrinsically generate self-sustained synchronous oscillations from the early neonatal period and how they are regulated remain unclear.<h4>Objective</h4>This study aimed to examine the endogenous rhythmicity of ARN kisspeptin neurons and its neural regulation using a neonatal organotypic slice culture model.<h4>Methods</h4>We monitored calcium (Ca2+) dynamics in real-time from individual ARN kisspeptin neurons in neonatal organotypic explant cultures of Kiss1-IRES-Cre mice transd"],"journal":["Neuroendocrinology"],"pagination":["1010-1027"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7592953"],"repository":["biostudies-literature"],"pubmed_title":["Kisspeptin Neuron-Specific and Self-Sustained Calcium Oscillation in the Hypothalamic Arcuate Nucleus of Neonatal Mice: Regulatory Factors of its Synchronization."],"pmcid":["PMC7592953"],"pubmed_authors":["Kim D","Lee S","Jang S","Park I","Heo WD","Ku K","Kim K","Kim J","Choe HK","Choi M","Son GH"],"additional_accession":[]},"is_claimable":false,"name":"Kisspeptin Neuron-Specific and Self-Sustained Calcium Oscillation in the Hypothalamic Arcuate Nucleus of Neonatal Mice: Regulatory Factors of its Synchronization.","description":"<h4>Introduction</h4>Synchronous and pulsatile neural activation of kisspeptin neurons in the arcuate nucleus (ARN) are important components of the gonadotropin-releasing hormone pulse generator, the final common pathway for central regulation of mammalian reproduction. However, whether ARN kisspeptin neurons can intrinsically generate self-sustained synchronous oscillations from the early neonatal period and how they are regulated remain unclear.<h4>Objective</h4>This study aimed to examine the endogenous rhythmicity of ARN kisspeptin neurons and its neural regulation using a neonatal organotypic slice culture model.<h4>Methods</h4>We monitored calcium (Ca2+) dynamics in real-time from individual ARN kisspeptin neurons in neonatal organotypic explant cultures of Kiss1-IRES-Cre mice transd","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-05-29T20:01:23.09Z","creation":"2025-05-29T20:01:23.09Z"},"accession":"S-EPMC7592953","cross_references":{"pubmed":["31935735"],"doi":["10.1159/000505922"]}}