{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Shen-Gunther J"],"funding":["Brooke Army Medical Center"],"pubmed_abstract":["Primary high-risk Human Papillomavirus (hrHPV) screening has recently become an accepted standalone or co-test with conventional cytology. Unfortunately, hrHPV singularly lacks specificity for cytopathological grade. However, mechanisms and markers of evolving virus-host interactions at the epigenome level may be harnessed as a better predictor of carcinogenesis. This study aimed to validate and expand the clinical performance of a multiparametric biomarker panel, referred to as the \"Molecular Pap smear\" based, on HPV genotype and <i>ADCY8</i>, <i>CDH8</i> and <i>ZNF582</i> CpG-methylation as a predictive classifier of cervical cytology. This prospective, cross-sectional study used an independent cohort of residual liquid-based cytology for HPV genotyping and epigenetic analysis. Extracted"],"journal":["Frontiers in microbiology"],"pagination":["595902"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7593258"],"repository":["biostudies-literature"],"pubmed_title":["Molecular Pap Smear: Validation of HPV Genotype and Host Methylation Profiles of <i>ADCY8</i>, <i>CDH8</i>, and <i>ZNF582</i> as a Predictor of Cervical Cytopathology."],"pmcid":["PMC7593258"],"pubmed_authors":["Asusta HB","Stacey W","Shen-Gunther J","Xia Q"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Pap Smear: Validation of HPV Genotype and Host Methylation Profiles of <i>ADCY8</i>, <i>CDH8</i>, and <i>ZNF582</i> as a Predictor of Cervical Cytopathology.","description":"Primary high-risk Human Papillomavirus (hrHPV) screening has recently become an accepted standalone or co-test with conventional cytology. Unfortunately, hrHPV singularly lacks specificity for cytopathological grade. However, mechanisms and markers of evolving virus-host interactions at the epigenome level may be harnessed as a better predictor of carcinogenesis. This study aimed to validate and expand the clinical performance of a multiparametric biomarker panel, referred to as the \"Molecular Pap smear\" based, on HPV genotype and <i>ADCY8</i>, <i>CDH8</i> and <i>ZNF582</i> CpG-methylation as a predictive classifier of cervical cytology. This prospective, cross-sectional study used an independent cohort of residual liquid-based cytology for HPV genotyping and epigenetic analysis. Extracted","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-07-09T11:19:36.07Z","creation":"2020-11-19T11:39:22Z"},"accession":"S-EPMC7593258","cross_references":{"pubmed":["33178175"],"doi":["10.3389/fmicb.2020.595902"]}}