biostudies-literatureUnknown155(12)Avolio AW<h4>Importance</h4>Expansion of donor acceptance criteria for liver transplant increased the risk for early allograft failure (EAF), and although EAF prediction is pivotal to optimize transplant outcomes, there is no consensus on specific EAF indicators or timing to evaluate EAF. Recently, the Liver Graft Assessment Following Transplantation (L-GrAFT) algorithm, based on aspartate transaminase, bilirubin, platelet, and international normalized ratio kinetics, was developed from a single-center database gathered from 2002 to 2015.<h4>Objective</h4>To develop and validate a simplified comprehensive model estimating at day 10 after liver transplant the EAF risk at day 90 (the Early Allograft Failure Simplified Estimation [EASE] score) and, secondarily, to identify early those patients with unJAMA surgerye204095https://www.ebi.ac.uk/biostudies/studies/S-EPMC7593884biostudies-literatureDevelopment and Validation of a Comprehensive Model to Estimate Early Allograft Failure Among Patients Requiring Early Liver Retransplant.PMC7593884Burra PDondossola DBassi DSchlegel AFerla FColledan MRossi MTeofili LCillo UMeli SGruttadauria SVivarelli MVitale ASpoletini GCarraro ADe Simone PBongini MAlrawashdeh WHammond JMontalti RCamagni SMuiesan PCaccamo LMazzaferro VDe Carlis LRomagnoli RDi Benedetto FCescon MPagano DLai QAvolio AWPatrono DVioli PAgnes SFranco ARavaioli MMagistri PfalseDevelopment and Validation of a Comprehensive Model to Estimate Early Allograft Failure Among Patients Requiring Early Liver Retransplant.<h4>Importance</h4>Expansion of donor acceptance criteria for liver transplant increased the risk for early allograft failure (EAF), and although EAF prediction is pivotal to optimize transplant outcomes, there is no consensus on specific EAF indicators or timing to evaluate EAF. Recently, the Liver Graft Assessment Following Transplantation (L-GrAFT) algorithm, based on aspartate transaminase, bilirubin, platelet, and international normalized ratio kinetics, was developed from a single-center database gathered from 2002 to 2015.<h4>Objective</h4>To develop and validate a simplified comprehensive model estimating at day 10 after liver transplant the EAF risk at day 90 (the Early Allograft Failure Simplified Estimation [EASE] score) and, secondarily, to identify early those patients with un2020-01-01T00:00:00Z2020 Dec2026-04-29T08:21:54.703Z2025-05-31T23:52:35.207ZS-EPMC75938843311239010.1001/jamasurg.2020.4095