{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Umkehrer S"],"funding":["European Research Council","Projekt DEAL"],"pagination":["18444"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7595203"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["In this study we aim to evaluate the assessment of bronchial pathologies in a murine model of lung transplantation with grating-based X-ray interferometry in vivo. Imaging was performed using a dedicated grating-based small-animal X-ray dark-field and phase-contrast scanner. While the contrast modality of the dark-field signal already showed several promising applications for diagnosing various types of pulmonary diseases, the phase-shifting contrast mechanism of the phase contrast has not yet been evaluated in vivo. For this purpose, qualitative analysis of phase-contrast images was performed and revealed pathologies due to previous lung transplantation, such as unilateral bronchial stenosis or bronchial truncation. Dependent lung parenchyma showed a strong loss in dark-field and absorpti"],"journal":["Scientific reports"],"pubmed_title":["A proof-of principal study using phase-contrast imaging for the detection of large airway pathologies after lung transplantation."],"pmcid":["PMC7595203"],"funding_grant_id":["AdG 695045","695045"],"pubmed_authors":["Morrone C","Herzen J","Aigner L","Dinkel J","Pfeiffer F","Umkehrer S","Hellbach K","Reiser MF","Yildirim AO"],"additional_accession":[]},"is_claimable":false,"name":"A proof-of principal study using phase-contrast imaging for the detection of large airway pathologies after lung transplantation.","description":"In this study we aim to evaluate the assessment of bronchial pathologies in a murine model of lung transplantation with grating-based X-ray interferometry in vivo. Imaging was performed using a dedicated grating-based small-animal X-ray dark-field and phase-contrast scanner. While the contrast modality of the dark-field signal already showed several promising applications for diagnosing various types of pulmonary diseases, the phase-shifting contrast mechanism of the phase contrast has not yet been evaluated in vivo. For this purpose, qualitative analysis of phase-contrast images was performed and revealed pathologies due to previous lung transplantation, such as unilateral bronchial stenosis or bronchial truncation. Dependent lung parenchyma showed a strong loss in dark-field and absorpti","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-22T18:51:46.887Z","creation":"2020-11-01T08:24:49Z"},"accession":"S-EPMC7595203","cross_references":{"pubmed":["33116193"],"doi":["10.1038/s41598-020-75185-4"]}}