biostudies-literatureUmkehrer SEuropean Research CouncilProjekt DEAL18444https://www.ebi.ac.uk/biostudies/studies/S-EPMC7595203biostudies-literatureUnknown10(1)In this study we aim to evaluate the assessment of bronchial pathologies in a murine model of lung transplantation with grating-based X-ray interferometry in vivo. Imaging was performed using a dedicated grating-based small-animal X-ray dark-field and phase-contrast scanner. While the contrast modality of the dark-field signal already showed several promising applications for diagnosing various types of pulmonary diseases, the phase-shifting contrast mechanism of the phase contrast has not yet been evaluated in vivo. For this purpose, qualitative analysis of phase-contrast images was performed and revealed pathologies due to previous lung transplantation, such as unilateral bronchial stenosis or bronchial truncation. Dependent lung parenchyma showed a strong loss in dark-field and absorptiScientific reportsA proof-of principal study using phase-contrast imaging for the detection of large airway pathologies after lung transplantation.PMC7595203AdG 695045695045Morrone CHerzen JAigner LDinkel JPfeiffer FUmkehrer SHellbach KReiser MFYildirim AOfalseA proof-of principal study using phase-contrast imaging for the detection of large airway pathologies after lung transplantation.In this study we aim to evaluate the assessment of bronchial pathologies in a murine model of lung transplantation with grating-based X-ray interferometry in vivo. Imaging was performed using a dedicated grating-based small-animal X-ray dark-field and phase-contrast scanner. While the contrast modality of the dark-field signal already showed several promising applications for diagnosing various types of pulmonary diseases, the phase-shifting contrast mechanism of the phase contrast has not yet been evaluated in vivo. For this purpose, qualitative analysis of phase-contrast images was performed and revealed pathologies due to previous lung transplantation, such as unilateral bronchial stenosis or bronchial truncation. Dependent lung parenchyma showed a strong loss in dark-field and absorpti2020-01-01T00:00:00Z2020 Oct2025-04-22T18:51:46.887Z2020-11-01T08:24:49ZS-EPMC75952033311619310.1038/s41598-020-75185-4